LAG-3, CTLA-4, CD8+, and recurrence-free survival (RFS), overall survival (OS) in patients with esophageal squamous cell carcinoma ESCC). (A) RFS by LAG-3, CTLA-4, and CD8+; (B) OS by LAG-3, CTLA-4, and CD8+. LAG-3, lymphocyte activation gene-3; CTLA-4, cytotoxic T-lymphocyte-associated antigen-4.