Table 1. Correlation between LAG-3 expression and clinicopathologic parameters.

Variables	LAG-3 expression		P
	Negative (N=114)	Positive (N=69)
Age (years), mean ± SD	62.1±9.5	64.7±8.4	0.058
≤65	70 [61]	36 [52]	0.220
>65	44 [39]	33 [48]
Sex, n [%]			0.870
Male	92 [81]	55 [80]
Female	22 [19]	14 [20]
Smoking, n [%]			0.646
Non-smoker	44 [39]	29 [42]
Smoker	70 [61]	40 [58]
Tumor location, n [%]			0.180
Upper	6 [5]	2 [3]
Middle	76 [67]	39 [57]
Lower	32 [28]	28 [41]
T stage, n [%]			0.635
T1	6 [5]	5 [7]
T2	43 [38]	31 [45]
T3	57 [50]	28 [41]
T4	8 [7]	5 [7]
N stage, n [%]			0.051
N0	80 [70]	37 [54]
N1	27 [24]	28 [41]
N2	7 [6]	4 [6]
Pathologic differentiation, n [%]			0.170
High	10 [9]	2 [3]
Moderate	79 [69]	46 [67]
Poor	25 [22]	21 [30]
Vascular invasion, n [%]			0.982
Absent	99 [87]	60 [87]
Present	15 [13]	9 [13]
Perineural involvement, n [%]			0.360
Absent	101 [89]	64 [93]
Present	13 [11]	5 [7]
Surgical type, n [%]			0.212
Sweet	39 [34]	27 [39]
Ivor-Lewis	42 [37]	30 [43]
McKeown	33 [29]	12 [17]
CTLA-4 expression, n [%]			<0.001
Negative	72 [63]	25 [36]
Positive	42 [37]	44 [64]
CD8 expression, n [%]			0.013
Negative	51 [45]	44 [64]
Positive	63 [55]	25 [36]

LAG-3, lymphocyte activation gene-3; CTLA-4, cytotoxic T-lymphocyte-associated antigen-4; TIL, tumor-infiltrating lymphocyte.