Table 3. Cox proportional-hazards regression model for recurrence-free survival (RFS) and overall survival (OS) in all patients.
| Variables | Recurrence-free survival | Overall survival | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | ||||||
| P | HR (95% CI) | P | P | HR (95% CI) | P | ||||
| Age (> 65 vs. ≤65) | 0.164 | 1.12 (0.72–1.75) | 0.625 | 0.153 | 1.24 (0.76–2.03) | 0.386 | |||
| Sex (female vs. male) | 0.724 | 0.844 | |||||||
| Smoking (current or ex vs. non-smoker) | 0.243 | 0.240 | |||||||
| Tumor location (middle & lower vs. upper) | 0.959 | 0.93 (0.29–3.01) | 0.903 | 0.411 | 2.31 (0.48–11.20) | 0.299 | |||
| T stage (T2-4 vs. T1) | 0.255 | 2.34 (0.67–8.12) | 0.181 | 0.396 | 1.48 (0.43–5.13) | 0.538 | |||
| N stage (N1-2 vs. N0) | <0.001 | 1.88 (1.20–2.94) | 0.006 | <0.001 | 1.97 (1.20–3.23) | 0.007 | |||
| Pathologic differentiation (moderate & poor vs. high) | 0.724 | 0.94 (0.36–2.44) | 0.892 | 0.377 | 1.22 (0.37–4.04) | 0.746 | |||
| Vascular invasion (present vs. absent) | 0.401 | 0.282 | |||||||
| Perineural involvement (present vs. absent) | 0.624 | 0.141 | 0.42 (0.15–1.19) | 0.102 | |||||
| Surgical type (McKeown vs. Sweet & Ivor-Lewis) | 0.485 | 1.20 (0.71–2.05) | 0.493 | 0.387 | 1.55 (0.88–2.71) | 0.128 | |||
| LAG-3 (positive vs. negative) | <0.001 | 1.72 (1.10–2.89) | 0.019 | <0.001 | 2.09 (1.24–3.53) | 0.006 | |||
| CTLA-4 (positive vs. negative) | <0.001 | 1.69 (1.04–2.73) | 0.033 | <0.001 | 1.47 (0.86–2.53) | 0.161 | |||
| CD8 (positive vs. negative) | 0.002 | 0.60 (0.38–0.94) | 0.025 | 0.001 | 0.56 (0.33–0.95) | 0.032 | |||
Variables with P value <0.2 in univariate models and variables clinically considered to have an impact on survival were analyzed in a multivariate analysis model. LAG-3, lymphocyte activation gene-3; CTLA-4, cytotoxic T-lymphocyte-associated antigen-4; TIL, tumor-infiltrating lymphocyte; HR, hazard ratio.