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. Author manuscript; available in PMC: 2020 Dec 6.
Published in final edited form as: J Mol Biol. 2019 Oct 15;431(24):4848–4867. doi: 10.1016/j.jmb.2019.10.005

Fig. 7.

Fig. 7.

Engagement of EBOV NP634 by sdAb ZC. (a) NP634 is shown in sky blue color with interface residues colored yellow, while sdAb interface residues are colored as follows: CDR1, orange; CDR2, green; CDR3, magenta; FR2, red; and FR3, salmon. (b) Top: antibody’s eye view of the epitope on EBOV NP634. Bottom: NP’s eye view of the sdAb paratope. Arrows indicate some of the major complementarities that are visible: yellow, M670 to the sdAb recess; green, CDR2 F52 to the NP basin. (c) Overlay of the sdAb ZC CDRs and FR2, aligned with the NP634’s eye view as cartoons with the bound/unbound color scheme as follows; CDR1, orange/beige; CDR2, green/yellow; CDR3, magenta/pink; FR2, red/salmon. EBOV, Zaire ebolavirus; sdAb, single-domain antibody; ZC, NP, nucleoprotein; FR2, framework 2.