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Regulation of brown-like adipose progenitor generation by RA and TGFβ pathways. Treatment of early differentiated hPSCs with retinoic acid (RA) for a short period of time (between days 3–5) inhibits the generation of brown-like adipose progenitors (BAPs) while promoting the generation of white adipose progenitors (WAPS). The TGFβ pathway inhibits both the generation of BAPs and their differentiation into mature adipocytes.
