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. 2020 Jan 21;10:3145. doi: 10.3389/fmicb.2019.03145

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Copyright © 2020 Chu, Zhai, Xu, Li, Li, Chen and Du.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Continuous light-induced PCOS-like changes in SD rats. (A) The average weekly BW of each group of rats. (B) The ovarian weight of each group of rats. (C) Representative estrous cycles of two groups. The upper and lower panels represent the L/D and L/L groups, respectively. D, diestrus; P, proestrus; E, estrus; M, metestrus. (D) Representative examples of ovarian HE-stain histology and average numbers of follicles and CL per ovary in L/D and L/L group. (E) Serum AMH concentration. (F) Serum T concentration. (G) Glucose tolerance test and the areas under the curves. (H) Fasting insulin level. Star, CLs; triangle, arrested antral follicle. CL, corpora lutea. N = 11/group. Values are expressed as means ± SEM. Significant differences between the two groups are indicated by asterisks (^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001).