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. 2020 Jan 21;10:3137. doi: 10.3389/fimmu.2019.03137

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Copyright © 2020 Yekula, Yekula, Muralidharan, Kang, Carter and Balaj.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glioma EVs mediate therapy resistance. Glioma EVs mediate the transfer of factors that induce a chemoradiation resistance phenotype in chemoradiation sensitive glioma cells. Glioma EVs also mediate drug export. APNG, alkyl purine-DNA-N-glycosylase; MGMT, O(6)-methylguanine DNA methyltransferase.