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Regulation of fetal gene program by the calcineurin-NFAT-mediated transcription in hypertrophic hearts. In the activated state, calcineurin mediates the dephosphorylation of NFAT and its subsequent nuclear translocation. The displacement of HDAC from the nucleus allows MEF2 mediated transcriptional activation. The culmination of these events results in activation of the fetal gene program, and ultimately cardiac remodeling
