Table 5.
ROC curve analysis determined between MCI and HC, adjusted for age and sex.
| MCI vs HC |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Prev. 5 % |
Prev. 10 % |
Prev. 16 % |
Prev. 20 % |
Prev. 36.7 % |
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| Sensitivity | Specificity | Cut-off | AUC, p | PPV | NPV | PPV | NPV | PPV | NPV | PPV | NPV | PPV | NPV | ||
| Ego 1st attempt | Error | 93.9 % | 80.7 % | 0.2519 | 0.917, p < 0.001* | 20.3 % | 99.6 % | 35 % | 99.1 % | 48 % | 98.5 % | 54.8 % | 98.1 % | 73.8 % | 95.6 % |
| Time | 96.9 % | 78.4 % | 0.2466 | 0.900, p < 0.001* | 19.1 % | 99.8 % | 33.3 % | 99.6 % | 46.1 % | 99.3 % | 52.9 % | 99 % | 72.2 % | 87.9 % | |
| Ego average of last 4 attempts | Error | 87.9 % | 83 % | 0.3153 | 0.901, p < 0.001* | 21.4 % | 99.2 % | 36.5 % | 98.4 % | 49.6 % | 97.3 % | 56.4 % | 96.5 % | 75 % | 92.2 % |
| Time | 100 % | 71.6 % | 0.1511 | 0.899, p < 0.001* | 15.6 % | 100 % | 28.1 % | 100 % | 40.1 % | 100 % | 46.8 % | 100 % | 67.1 % | 100 % | |
| Ego average of all 8 attempts | Error | 93.9 % | 76.1 % | 0.1956 | 0.915, p < 0.001* | 17.1 % | 99.6 % | 30.4 % | 99.1 % | 42.8 % | 98.5 % | 49.6 % | 98 % | 69.5 % | 95.6 % |
| Time | 100 % | 73.9 % | 0.2053 | 0.888, p < 0.001* | 16.8 % | 100 % | 29.9 % | 100 % | 42.2 % | 100 % | 48.9 % | 100 % | 69 % | 100 % | |
| Allo 1st attempt | Error | 100 % | 72.7 % | 0.1951 | 0.887, p < 0.001* | 16.2 % | 100 % | 28.9 % | 100 % | 41.1 % | 100 % | 47.8 % | 100 % | 68 % | 100 % |
| Time | 100 % | 75 % | 0.2109 | 0.895, p < 0.001* | 17.4 % | 100 % | 30.8 % | 100 % | 43.2 % | 100 % | 50 % | 100 % | 69.9 % | 100 % | |
| Allo average of last 4 attempts | Error | 100 % | 70.5 % | 0.1707 | 0.879, p < 0.001* | 15.1 % | 100 % | 27.4 % | 100 % | 39.2 % | 100 % | 45.9 % | 100 % | 63.3 % | 100 % |
| Time | 100 % | 70.5 % | 0.2059 | 0.892, p < 0.001* | 15.1 % | 100 % | 27.4 % | 100 % | 39.2 % | 100 % | 45.9 % | 100 % | 66.3 % | 100 % | |
| Allo average of all 8 attempts | Error | 100 % | 71.6 % | 0.1642 | 0.896, p < 0.001* | 15.6 % | 100 % | 28.1 % | 100 % | 40.1 % | 100 % | 46.8 % | 100 % | 67.1 % | 100 % |
| Time | 100 % | 73.9 % | 0.1831 | 0.890, p < 0.001* | 16.8 % | 100 % | 29.9 % | 100 % | 42.2 % | 100 % | 48.9 % | 100 % | 69 % | 100 % | |
| Combined Allo-Ego 1st attempt | Error | 90.9 % | 80.7 % | 0.2294 | 0.920, p < 0.001* | 15.5 % | 99.4 % | 34.4 % | 98.8 % | 47.3 % | 97.9 % | 54.1 % | 97.3 % | 73.2 % | 93.9 % |
| Time | 96.9 % | 77.3 % | 0.2367 | 0.886, p < 0.001* | 18.3 % | 99.8 % | 32.2 % | 99.6 % | 44.8 % | 99.2 % | 51.6 % | 99 % | 71.2 % | 97.7 % | |
| Combined Allo-Ego average of last 4 attempts | Error | 97 % | 73.9 % | 0.1787 | 0.906, p < 0.001* | 16.4 % | 99.8 % | 29.2 % | 99.6 % | 41.4 % | 99.2 % | 48.2 % | 99 % | 68.3 % | 97.7 % |
| Time | 100 % | 73.9 % | 0.1886 | 0.889, p < 0.001* | 16.8 % | 100 % | 29.9 % | 100 % | 42.2 % | 100 % | 48.9 % | 100 % | 69 % | 100 % | |
| Combined Allo-Ego average of all 8 attempts | Error | 93.9 % | 80.7 % | 0.2453 | 0.917, p < 0.001* | 20.4 % | 99.6 % | 35.1 % | 99.2 % | 48.1 % | 98.6 % | 54.9 % | 98.1 % | 73.8 % | 95.8 % |
| Time | 96.9 % | 77.3 % | 0.2624 | 0.888, p < 0.001* | 18.3 % | 99.8 % | 32.2 % | 99.6 % | 44.8 % | 99.2 % | 51.6 % | 99 % | 71.2 % | 97.7 % | |
| Ego average of first 4 attempts | Error | 93.9 % | 77.3 % | 0.1874 | 0.920, p < 0.001* | 17.9 % | 99.6 % | 31.5 % | 99.1 % | 44.1 % | 98.5 % | 50.8 % | 98.1 % | 70.6 % | 95.6 % |
| Allo average of first 4 attempts | Error | 100 % | 70.5 % | 0.1658 | 0.893, p < 0.001* | 15.1 % | 100 % | 27.4 % | 100 % | 39.2 % | 100 % | 45.9 % | 100 % | 66.3 % | 100 % |
| Combined Allo-Ego average of first 4 attempts | Error | 90.9 % | 83 % | 0.2774 | 0.917, p < 0.001* | 22 % | 99.4 % | 37.3 % | 98.8 % | 50.5 % | 98 % | 57.2 % | 97.3 % | 75.6 % | 94 % |
Allo, allocentric; AUC, area under the curve; Ego, egocentric; HC, healthy control; MCI, mild cognitive impairment; NPV, negative predictive value; PPV, positive predictive value; Prev, prevalence.