Table 8.
ROC curve analysis between MCI and HC group, unadjusted for age and sex.
| MCI vs HC | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Prev. 5% | Prev. 10% | Prev. 16% | Prev. 20% | Prev. 36.7% | |||||||||||
| Sensitivity | Specificity | Cut-off | AUC, p | PPV | NPV | PPV | NPV | PPV | NPV | PPV | NPV | PPV | NPV | ||
| Ego 1st attempt | Error | 85.7% | 68.1% | 33.6 cm | 0.807, p<0.001* | 12.4% | 98.9% | 23% | 97.7% | 33.9% | 96.2% | 40.2% | 95% | 60.9% | 89.1% |
| Ego average of last 4 attempts | Error | 100% | 71.4% | 23.2 cm | 0.875, p<0.001* | 15.5% | 100% | 28% | 100% | 40% | 100% | 46.6% | 100% | 67% | 100% |
| Ego average of all 8 attempts | Error | 92.9% | 82.4% | 24.05 cm | 0.918, p<0.001* | 21.7% | 99.5% | 37% | 99.1% | 50.1% | 98.4% | 56.9% | 97.9% | 75.4% | 95.2% |
| Allo 1st attempt | Error | 64.3% | 87.3% | 44 cm | 0.747, p=0.003* | 21% | 97.9% | 36% | 95.7% | 49.1% | 92.8% | 55.9% | 90.7% | 74.6% | 80.8% |
| Allo average of last 4 attempts | Error | 71.4% | 82.4% | 30.5 cm | 0.794, p<0.001* | 17.6% | 98.2% | 31.1% | 96.3% | 43.6% | 93.8% | 50.4% | 92% | 70.2% | 83.2% |
| Allo average of all 8 attempts | Error | 85.7% | 78% | 33.9 cm | 0.825, p<0.001* | 17% | 99% | 30.2% | 98% | 42.6% | 96.6% | 49.3% | 95.6% | 69.3% | 90.4% |
| Combined Allo-Ego 1st attempt | Error | 64.3% | 91.2% | 53.35 cm | 0.849, p<0.001* | 27.8% | 98% | 44.8% | 95.8% | 58.2% | 93.1% | 64.6% | 91.1% | 80.9% | 81.5% |
| Combined Allo-Ego average of last 4 attempts | Error | 78.6% | 90.1% | 38.35 cm | 0.902, p<0.001* | 29.5% | 98.8% | 46.9% | 97.4% | 60.2% | 95.7% | 66.5% | 94.4% | 82.2% | 87.9% |
| Combined Allo-Ego average of all 8 attempts | Error | 85.7% | 84.6% | 35.55 cm | 0.895, p<0.001* | 22.7% | 99.1% | 38.2% | 98.2% | 51.5% | 96.9% | 58.2% | 95.9% | 76.3% | 91.1% |
| Ego average of first 4 attempts | Error | 92.9% | 89% | 35.35 cm | 0.917, p<0.001* | 30.8% | 99.6% | 48.4% | 99.1% | 61.7% | 98.5% | 67.9% | 98% | 83% | 95.6% |
| Allo average of first 4 attempts | Error | 64.3% | 87.9% | 46.55 cm | 0.797, p<0.001* | 21.9% | 97.9% | 37.1% | 95.7% | 50.3% | 92.8% | 57.1% | 90.8% | 75.5% | 80.9% |
| Combined Allo-Ego average of first 4 attempts | Error | 71.4% | 89% | 43.85 cm | 0.832, p<0.001* | 25.5% | 98.3% | 41.9% | 96.6% | 55.3% | 94.2% | 61.9% | 92.6% | 79% | 84.3% |
Allo, allocentric; AUC, area under the curve; ego, egocentric; HC, healthy control; MCI, mild cognitive impairment; NPV, negative predictive value; PPV, positive predictive value; Prev, prevalence.