Table 9.
ROC curve analysis between MCI and HC group, adjusted for age and sex.
| MCI vs HC | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Prev. 5% | Prev. 10% | Prev. 16% | Prev. 20% | Prev. 36.7% | |||||||||||
| Sensitivity | Specificity | Cut-off | AUC, p | PPV | NPV | PPV | NPV | PPV | NPV | PPV | NPV | PPV | NPV | ||
| Ego 1st attempt | Error | 86.7% | 63% | 29.3 cm | 0.805, p=0.001* | 11% | 98.9% | 20.7% | 97.7% | 30.9% | 96.1% | 36.9% | 95% | 57.6% | 89.1% |
| Ego average of last 4 attempts | Error | 100% | 66.7% | 22.65 cm | 0.873, p<0.001* | 13.6% | 100% | 25% | 100% | 36.4% | 100% | 42.9% | 100% | 63.5% | 100% |
| Ego average of all 8 attempts | Error | 93.3% | 77.8% | 29.65 cm | 0.909, p<0.001* | 18.1% | 99.5% | 31.8% | 99.1% | 44.5% | 98.4% | 51.2% | 97.9% | 70.9% | 95.2% |
| Allo 1st attempt | Error | 66.7% | 77.8% | 42 cm | 0.670, p=0.070 | 13.7% | 97.8% | 25% | 95.5% | 36.4% | 92.5% | 42.9% | 90.3% | 63.5% | 80.1% |
| Allo average of last 4 attempts | Error | 66.7% | 81.5% | 37.05 cm | 0.775, p=0.003* | 15.9% | 97.9% | 28.6% | 95.7% | 40.7% | 92.8% | 47.4% | 90.7% | 67.6% | 80.8% |
| Allo average of all 8 attempts | Error | 86.7% | 63% | 33.9 cm | 0.773, p=0.004* | 11% | 98.9% | 20.7% | 97.7% | 30.9% | 96.1% | 36.9% | 95% | 57.6% | 89.1% |
| Combined Allo-Ego 1st attempt | Error | 60% | 96.3% | 68.4 cm | 0.849, p<0.001* | 46% | 97.9% | 64.3% | 95.6% | 75.5% | 92.7% | 80.2% | 90.6% | 90.4% | 80.6% |
| Combined Allo-Ego average of last 4 attempts | Error | 80% | 88.9% | 35.6 cm | 0.914, p<0.001* | 27.5% | 98.8% | 44.5% | 97.6% | 57.9% | 95.9% | 64.3% | 94.7% | 80.7% | 88.5% |
| Combined Allo-Ego average of all 8 attempts | Error | 73.3% | 96.3% | 40.75 cm | 0.902, p<0.001* | 51% | 98.6% | 68.8% | 97% | 79.1% | 95% | 83.2% | 93.5% | 92% | 86.2% |
| Ego average of first 4 attempts | Error | 93.3% | 88.9% | 35.35 cm | 0.904, p<0.001* | 30.7% | 99.6% | 48.3% | 99.2% | 61.6% | 98.6% | 67.8% | 98.2% | 83% | 95.8% |
| Allo average of first 4 attempts | Error | 66.7% | 77.8% | 46.55 cm | 0.753, p=0.007* | 13.7% | 97.8% | 25% | 95.5% | 36.4% | 92.5% | 42.9% | 90.3% | 63.5% | 80.1% |
| Combined Allo-Ego average of first 4 attempts | Error | 66.7% | 96.3% | 54.8 cm | 0.847, p<0.001* | 48.7% | 98.2% | 66.7% | 96.3% | 77.4% | 93.8% | 81.8% | 92% | 91.3% | 83.3% |
Allo, allocentric; AUC, area under the curve; Ego, egocentric; HC, healthy control; MCI, mild cognitive impairment; NPV, negative predictive value; PPV, positive predictive value; Prev, prevalence.