Figure 1.
Schematic diagram of the updated human sinus node cell model. Compared to the original Fabbri et al. model (10), a small conductance calcium-activated potassium current (ISK) was added, and the model took into account the dependency of gKr on [K+]o, as well as the dynamic intracellular concentration changes of not only calcium but also sodium and potassium. Details regarding the updated Loewe-Lutz-Fabbri-Severi model, including the full list of parameters and initial values, are available on www.cellml.org. To see this figure in color, go online.