Figure 3.

Action potential (AP) and calcium transient (CaT) feature dependency on extracellular calcium concentration [Ca²⁺]_o. (A) Cycle length of spontaneous sinus node cell beating, (B) APD₉₀, (C) maximal diastolic potential, (D) AP overshoot, (E) DDR₁₀₀ after MDP, (F) AP upstroke velocity, (G) CaT duration at 50%, and (H) CaT amplitude are shown. The thick blue line represents the scenario in which all currents were exposed to the altered [Ca²⁺]_o, whereas the thin lines represent scenarios in which only one current was exposed to the altered concentration while the other two were computed with 1.8 mM. To see this figure in color, go online.