Figure 7.

Changes of ionic concentrations (A–F) during DD upon changes of extracellular calcium concentration [Ca²⁺]_o. (i) Maximal and minimal concentrations over entire DD phase, (ii) maximal and minimal concentrations over first 100 ms of DD, and (iii) maximal and minimal concentrations over the late depolarization phase (excluding the first 100 ms) are shown. The solid lines represent the scenario in which all currents were exposed to the altered [Ca²⁺]_o, whereas the dashed lines represent scenarios in which only I_CaL was exposed to the altered concentration while the other two (I_CaT, I_NaCa) were computed with 1.8 mM. To see this figure in color, go online.