Figure 3.

Arrhythmia within idealized infarct models with different remodeled isthmuses. V_m maps at different times show arrhythmia induction following the S1–S2 pacing protocol. (A) Nonsustained arrhythmia in a 2D sheet with prolonged APD in the isthmus is shown. (B) Sustained arrhythmia in a 2D sheet with reduced INa (30%) in the isthmus is shown. (C) Sustained arrhythmia in a 2D sheet with reduced INa (70%) and fibrosis (FIB = 50%) in the isthmus is shown. Arrows represent successful propagation. Lined arrows represent conduction block. Re-entry induction in the idealized infarct models shown in (A–C) can be fully appreciated in Videos S1, S2, and S3, respectively. To see this figure in color, go online.