Figure 5.

Distributions of collagen morphology described using elongation $\left(\mathbb{E}\right)$ and flatness $\left(\mathbb{F}\right)$ parameters in the LV midwall of 12-month-old (top) and 24-month-old (bottom) SHR (right) and WKY (left) rat hearts. Confocal image volumes (400 × 400 × 200 μm): myocytes have variable intensity, whereas collagen appears brighter. Dark gaps in the confocal images indicate the cleavage planes. Heat maps: data points represent collagen shape for each ROI, with the red and blue colorscale indicating high and low normalized density of collagen shapes. To see this figure in color, go online.