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. 2020 Feb;20(2):208–219. doi: 10.1016/S1473-3099(19)30571-7

Figure 2.

Figure 2

Geometric mean times increases in faecal secretory IgA (A) and plasma IgA (B) responses in infants aged 6–11 months

Horizontal lines indicate the geometric mean response for the group, whereas the circles represent individual responses. Times increases were calculated as the post-immunisation response (the highest response on either day 7 after the first dose or day 5 or 14 after the second dose) divided by pre-immunisation antibody levels. Faecal secretory IgA responses were the ratio between antigen-specific faecal secretory IgA antibody titres divided by total secretory IgA in preimmunisation and corresponding postimmunisation samples. Significant differences between vaccine (n=131) and placebo (n=46) recipients in faecal secretory IgA times increases were observed for CFA/I (p=0·0050), CS3 (p=0·0005), CS5 (p=0·026), CS6 (p=0·028), and LTB (p=0·0020) before Holm's-Bonferroni adjustment and for CFA/I (p=0·015), CS3 (p=0·0025), and LTB (p=0·0080) after adjustment. Significant differences in geometric mean times increases in plasma IgA between vaccine (n=148) and placebo (n=50) recipients were seen for CS3 (p=0·013) and LTB (p<0·0001) before Holm's-Bonferroni adjustment and for LTB (p<0·0001) after adjustment.