Table 3.
Estimated global PAF and number of incident HIV infections in 2016 attributable to HSV-2 infection, by age, sex, and risk population
|
PAF of incident HIV infections from sexual transmission attributable to HSV-2 infection |
Number of incident HIV infections attributable to all HSV-2 infections* | Number of incident HIV infections from sexual transmission*† | ||||
|---|---|---|---|---|---|---|
| All HSV-2 infections | Established HSV-2 infections | Recently acquired HSV-2 infections | ||||
| General population | ||||||
| Women | ||||||
| 15–24 years | 30·8% (22·3–40·2) | 21·4% (11·8–31·7) | 9·4% (5·2–15·6) | 105 000 (61 000–156 000) | 340 000 | |
| 25–49 years | 36·4% (24·7–46·9) | 33·7% (21·1–44·8) | 2·7% (1·5–4·8) | 127 000 (76 000–182 000) | 348 000 | |
| 15–49 years | 34·8% (23·5–45·0) | 29·6% (17·2–40·6) | 5·1% (2·8–8·9) | 239 000 (140 000–357 000) | 689 000 | |
| Men | ||||||
| 15–24 years | 17·9% (11·0–27·1) | 14·6% (8·1–23·6) | 3·3% (0·9–7·5) | 41 000 (20 000–72 000) | 231 000 | |
| 25–49 years | 30·2% (19·6–40·9) | 28·4% (17·7–39·2) | 1·8% (0·5–4·1) | 148 000 (76 000–245 000) | 492 000 | |
| 15–49 years | 26·2% (16·9–37·3) | 23·9% (14·6–34·7) | 2·3% (0·7–5·3) | 189 000 (99 000–314 000) | 723 000 | |
| Women and men combined | ||||||
| 15–24 years | 23·2% (16·8–31·0) | 18·6% (12·8–25·4) | 4·6% (1·7–10·1) | 133 000 (94 000–181 000) | 572 000 | |
| 25–49 years | 32·4% (25·4–40·2) | 30·6% (23·3–38·5) | 1·8% (0·7–4·1) | 272 000 (207 000–347 000) | 840 000 | |
| Key risk populations‡ | ||||||
| Female sex workers | 26·7% (0·0–56·5) | 26·7% (0·0–56·5) | .. | 20 000 (0–44 000)§ | 77 000 | |
| Men who have sex with men | 19·9% (8·7–28·7) | 19·9% (8·7–28·7) | .. | 40 000 (17 000–62 000)§ | 203 000 | |
Data are % (95% UI), n (95% UI), or n. The number of incident HIV infections attributable to HSV-2 infection was calculated for each age and sex group separately; therefore, estimates do not sum exactly across rows. PAF=population attributable fraction. UI=uncertainty interval.
Estimates are shown to the nearest thousand; they are based on 2016 HIV incidence data, 2012 HSV-2 infection estimates,1 key population HSV-2 prevalence data reviewed as part of the 2012 work on HSV-2 infection estimates,1 RR estimates from a review of literature published up until 2017,6 and key population breakdown of HIV incidence for 2015.23
Denominators for calculation of PAFs.
Only established HSV-2 infections were considered, and not recently acquired ones.
These numbers form a subset of the global numbers and are not in addition to them.