Table 1.
Baseline characteristics of patients, and univariate logistic regression analysis of clinical risk factors brain for metastasis
| Variable | N | Brain Mets (%) | Odds Ratio | 95% CL | 95% CU | P |
|---|---|---|---|---|---|---|
| Age (decade) | 457481 | NA | 0.672 | 0.667 | 0.678 | <.001 |
| Sex | ||||||
| M | 237831 | 24861 (10.45) | 1 | |||
| F | 219650 | 22685 (10.33) | 0.987 | 0.968 | 1.006 | 0.165 |
| Race | ||||||
| White | 389631 | 39164 (10.05) | 1 | |||
| Black | 50745 | 6068 (11.96) | 1.215 | 1.181 | 1.251 | <.001 |
| Other/Unknown | 17105 | 2314 (13.53) | 1.401 | 1.339 | 1.465 | <.001 |
| Histology | ||||||
| Squamous | 134046 | 6552 (4.89) | 1 | |||
| Adenocarcinoma | 235341 | 30560 (12.99) | 2.903 | 2.824 | 2.985 | <.001 |
| Large cell | 5455 | 782 (14.34) | 3.256 | 3.006 | 3.526 | <.001 |
| Others | 82639 | 9652 (11.68) | 2.573 | 2.490 | 2.658 | <.001 |
| Tumor size | ||||||
| 0–3cm | 177268 | 11682 (6.59) | 1 | |||
| 3.1–5cm | 104742 | 12013 (11.47) | 1.836 | 1.788 | 1.886 | <.001 |
| >5cm | 101799 | 13961 (13.71) | 2.253 | 2.195 | 2.312 | <.001 |
| Unknown | 73672 | 9890 (13.42) | 2.198 | 2.137 | 2.261 | <.001 |
| Tumor grade | ||||||
| I | 33830 | 762 (2.25) | 1 | |||
| II | 98242 | 4475 (4.56) | 2.071 | 1.916 | 2.238 | <.001 |
| III | 128543 | 13908 (10.82) | 5.264 | 4.889 | 5.668 | <.001 |
| IV | 4737 | 572 (12.08) | 5.959 | 5.322 | 6.672 | <.001 |
| Unknown | 192129 | 27829 (14.48) | 7.349 | 6.832 | 7.905 | <.001 |
| N stage | ||||||
| N0 | 204203 | 10441 (5.11) | 1 | |||
| N1 | 35147 | 4323 (12.3) | 2.602 | 2.507 | 2.702 | <.001 |
| N2 | 124777 | 19210 (15.4) | 3.377 | 3.293 | 3.462 | <.001 |
| N3 | 45366 | 7332 (16.16) | 3.577 | 3.465 | 3.693 | <.001 |
| Unknown | 47988 | 6240 (13) | 2.773 | 2.683 | 2.867 | <.001 |