Table 2.

Supplementary Material on Central Nervous System Vital Signs (CNS VS).

Cognitive domain	CNS VS test	Domain score calculations (“Formulas for Calculating Domain Scores,” n.d.)	Description
Verbal memory	Verbal memory test (VBM)	VBM direct correct hits + VBM direct correct passes + VBM delayed correct hits + VBM delayed correct passes	Learning a list of 15 words, with a direct recognition, and after six more tests a delayed recognition trial
Visual memory	Visual memory test (VIM)	VIM direct correct hits + VIM direct correct passes + VIM delayed correct hits + VIM delayed correct passes	Learning a list of 15 geometric figures, with a direct recognition, and after six more tests a delayed recognition trial
Processing speed	Symbol digit coding (SDC)	SDC correct responses—SDC errors	Number 1 to 9 correspond to different symbols. As many correct numbers as possible have to be filled out underneath the presented symbols in 90 seconds
Psychomotor speed	Finger-tapping test (FTT); SDC	FTT taps right hand + FTT taps left hand + SDC correct responses	Pressing the space bar with the index finger as many times in 10 seconds, above mentioned
Reaction time	Stroop test (ST)	(ST Part II reaction time on correct responses + ST Part III reaction time on correct responses)/2	In Part I, pressing the space bar as soon as the word RED, YELLOW, BLUE, and GREEN appear—In Part II, pressing the space bar as the color of the word matches what the word says—In Part III, pressing the space bar as the color of the word does not match what the word says
Complex attention	Continuous performance test (CPT); Shifting attention test (SAT); ST	Stroop commission errors + SAT errors + CPT commission errors + CPT omission errors	Responding to a target stimulus “B” but no any other letter. Shifting from one instruction to another quickly and accurately (matching geometric objects either by shape or color); Above mentioned
Cognitive flexibility	SAT; ST	SAT correct—SAT errors—ST commission errors	Above mentioned