Table 1.
Demographic data, metabolic profiles, and levels of pro-inflammatory cytokines between patients with bipolar disorder and unipolar depression
| Bipolar disorder (n = 72) | Unipolar depression (n = 64) | P value | |
|---|---|---|---|
| Demographic data | |||
| Sex (M/F, n) | 27/45 | 19/45 | 0.336 |
| Age (SD) | 39.5 (12.3) | 39.0 (15.3) | 0.837 |
| Metabolic profiles | |||
| BMI (SD) | 26.6 (5.2) | 23.7 (4.03) | 0.002* |
| Glucose (SD) | 89.8 (16.4) | 89.1 (9.2) | 0.758 |
| Triglyceride (SD) | 119.5 (93.5) | 107.4 (69.9) | 0.400 |
| High density lipoprotein (HDL) | 56.4 (16.9) | 56.8 (13.4) | 0.876 |
| Leptin (SD) | 11,431.2 (10,944.5) | 9013.4 (7372.7) | 0.159 |
| Insulin (SD) | 9.65 (14.78) | 8.12 (14.04) | 0.551 |
| Adiponectin (SD) | 6158.4 (4670.2) | 7505.1 (5664.9) | 0.141 |
| Metabolic syndrome (%) | 23.6% | 22.6% | 0.527 |
| Inflammation index (pg/ml) | |||
| sIL-6R (SD) | 36,917.86 (11,001.38) | 29,420.91 (8282.58) | < 0.001** |
| sIL-2R (SD) | 747.39 (323.22) | 671.83 (246.70) | 0.135 |
| CRP (SD) | 1751.60 (1929.26) | 1823.09 (2289.56) | 0.840 |
| sTNFR1 (SD) | 1216.55 (468.646) | 748.46 (161.44) | < 0.001** |
BMI body mass index, SD standard deviation, MARDS Montgomery-Åsberg Depression Rating Scale, YAMRS The Young Mania Rating Scale; Global Assessment of Function Scale, sIL-2R soluble IL-2 receptor, sIL-6R soluble IL-6 receptor, CRP C-reactive protein, sTNFR1 soluble tumor necrosis factor-α receptor-1
*P < 0.05, **P < 0.001