Table 2.

Comparison of cytokines among patients with unipolar depression taking different types of antidepressant

	SSRI (n = 19)	SNRI (n = 18)	NDRI (n = 11)	NaSSA (n = 4)	Agomelatine (n = 9)	Significance
C-reactive protein (CRP) (pg/ml)	2322.6 ± 3028.6	999.8 ± 1408.8	3133.2 ± 2206.4	978.3 ± 605.4	1366.4 ± 1930.0	n.s.
Soluble interleukin-2 receptor (sIL-2R) (pg/ml)	643.7 ± 211.2	611.5 ± 177.7	851.0 ± 358.3	825.1 ± 316.8	561.7 ± 220.8	n.s.
Soluble interleukin-6 receptor (sIL-6R) (pg/ml)	29,504.2 ± 5970.7	28,075.4 ± 9047.5	29,518.2 ± 9497.3	35,502.9 ± 8097.8	28,205.8 ± 11,328.8	n.s.
Soluble tumor necrosis factor receptor type 1 (sTNF-R1) (pg/ml)	774.7 ± 134.7	753.1 ± 147.2	779.0 ± 235.0	863.9 ± 583.3	653.0 ± 181.7	n.s.

NaSSA noradrenergic and specific serotonergic antidepressant, NDRI norepinephrine dopamine reuptake inhibitor, SNRI serotonin-norepinephrine reuptake inhibitor, SSRI selective serotonin reuptake inhibitor, n.s. not significant