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. 2020 Jan 28;16:1744806920903150. doi: 10.1177/1744806920903150

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© The Author(s) 2020

Creative Commons CC BY: This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Colonic afferent responses to noxious ramp and repeat phasic distension in mouse and NMR. (a) Example rate histograms of colonic lumbar splanchnic nerve activity from mouse and NMR with intraluminal pressure trace and neurogram trace following ramp distension (0–80 mmHg) and repeat phasic distension (0–80 mmHg, 60 s, 9 min intervals). Below, expanded neurogram traces showing NMR before and after phasic distension and an example trace showing three action potentials. (b) Mean firing rates to ramp distension at 5 mmHg increments in mouse and NMR (P = 0.51, N = 8–9, mixed-model ANOVA). (c) Average change in peak firing rate during repeat phasic distension in mouse and NMR (P = 0.98, two-way repeated-measures ANOVA). NMR: naked mole-rat.