Figure 3.

Extracellular acid evokes mechanical hypersensitivity in NMR, but not mouse. (a) Example rate histograms of colonic splanchnic nerve activity from mouse and NMR with accompanying pressure trace showing bath superfusion of pH 4.0 Krebs buffer (50 mL) and subsequent repeat (×3) phasic distension. (b) Mean increase in peak firing after application of pH 4.0 (*P = 0.02, N = 9, unpaired t test). (c) Peak firing change to phasic distension after superfusion with pH 4.0 solution. The response to phasic distension in NMR, but not mouse, was significantly sensitised by acid (***P < 0.01, N = 9, two-way repeated-measures ANOVA with Holm–Sidak’s post hoc). NMR: naked mole-rat.