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. 2020 Jan 28;16:1744806920903150. doi: 10.1177/1744806920903150

Figure 4.

Figure 4.

Colonic afferent excitation to bradykinin is blunted in NMR, but mechanical sensitisation is unaffected. (a) Example rate histograms of colonic splanchnic nerve activity from mouse and NMR with accompanying pressure trace showing addition of 1 µM bradykinin (20 mL) and subsequent repeat (×3) phasic distension. (b) Mean increase in peak firing after application of 1 µM bradykinin (***P < 0.001, N = 9, unpaired t test). (c) Peak firing change to phasic distension after superfusion with 1 µM bradykinin. The response to phasic distension in both NMR and mouse was significantly sensitised by application of bradykinin (**P < 0.01 vs. ninth distension in NMR, #P < 0.05 vs. ninth distension in mouse, N = 9, two-way repeated-measures ANOVA with Holm–Sidak’s post hoc). Inset, phasic distension responses in both NMR and mouse normalised to the pre-bradykinin distension response (**P < 0.01 vs. normalised ninth distension in NMR, ####P < 0.0001 vs. normalised ninth distension in mouse, N = 9, two-way repeated-measures ANOVA with Holm–Sidak’s post hoc). NMR: naked mole-rat.