Table 2.
Hemodynamic and metabolic measurements as well as parameters of lung function in GRdim/dim and GR+/+ mice intraperitoneally challenged with lipopolysaccharide (LPS) or vehicle (phosphate buffered saline, PBS) at the end of the experiment.
| Parameters | Resuscitation (IV crystalloids and norepinephrine) | |||
|---|---|---|---|---|
|
GR+/+ + Vehicle (n = 8) |
GRdim/dim + Vehicle (n = 7) |
GR+/+ + LPS (n = 9) |
GRdim/dim + LPS (n = 11) |
|
| Bodyweight [g] |
26.7 (23.0; 31.6) | 24.6 (20.6; 32.7) | 29.0 (26.6; 31.1) | 24.0 (22.7; 28.2) |
| Heart rate [beats·min−1] |
478 (335; 518) | 551 (520; 558) | 529 (471; 557) | 523 (460; 580) |
| Mean arterial pressure [mmHg] |
61 (56; 65) | 54 (52; 61) | 56 (49; 58) | 49 (43; 51) |
| PaCO2 [mmHg] |
37 (30; 45) | 41 (39; 44) | 34 (33; 47) | 43 (40; 46) |
| Minute ventilation [mL·kg−1·min−1] |
905 (838; 1,058) | 1,000 (980; 1,080) | 1,000 (960; 1,040) | 1,060 (980; 1,170) |
| Horovitz-Index [mmHg] |
465 (409; 498) | 363 (342; 371) | 349 (302; 463) | 327 (291; 352) |
| Glucose [mg·dL−1] |
129 (121; 147) | 139 (136; 176) | 78 (60; 89) | 94 (80; 183) |
| Arterial pH | 7.28 (7.26; 7.34) | 7.23 (7.19; 7.28) | 7.14 (7.12; 7.32) | 7.12 (6.99;7.20) |
| Arterial base excess [mmol·L−1] |
−8.4 (−11.3; −5.6) | −7.9 (−10.5; −7.4) | −11.0 (−13.2; −10.2) | –14.5 (–19.9; –12.0)# |
| Lactate [mmol·L−1] |
1.1 (0.8; 1.6) | 1.5 (1.2; 2.1) | 2.8 (2.1; 3.1) | 5.3 (3.9; 6.6)# |
| Hemoglobin [g·dL−1] |
8.7 (8.3; 10.6) | 9.0 (8.6; 11.4) | 8.2 (7.3; 10.1) | 9.0 (8.0; 9.7) |
| Urinary output [μL] |
1,796 (997; 2,413) | 2,309 (1,494; 3,628) | 881 (646; 1,906) | 969 (514; 1,060)# |
#
P <0.05 vs. GRdim PBS. PBS = phosphate buffered saline (vehicle), 10 μl·g−1. LPS = Lipopolysaccharide from Escherichia coli (055:B5), 10 mg·kg−1. Data is shown as median (25th and 75th percentile).