Table 4.
Quantification of lung histology analysis in GRdim/dim and GR+/+ mice that underwent an intraperitoneally challenge with lipopolysaccharide (LPS) or vehicle (phosphate buffered saline, PBS) and were resuscitated for 6 h thereafter.
| Parameters | Resuscitation (IV crystalloids and norepinephrine) | |||
|---|---|---|---|---|
|
GR+/+ + Vehicle (n = 8) |
GRdim/dim + Vehicle (n = 7) |
GR+/+ + LPS (n = 5) |
GRdim/dim + LPS (n = 6) |
|
| Alveolar membrane thickening | 1.0 (0.9; 1.0) | 1.5 (1.0; 2.0) | 1.0 (1.0; 2.0) | 1.5 (1.0; 2.0) |
| Dystelectasis | 0.5 (0.0; 0.5) | 0.5 (0.0; 1.0) | 0.0 (0.0; 0.0) | 0.3 (0.0; 0.5) |
| Emphysema | 2.0 (2.0; 2.0) | 2.0 (1.8; 2.0) | 2.5 (2.5; 2.5) | 2.5 (2.0; 3.0) |
| Lymphocytes | 1.0 (1.0; 1.3) | 2.0 (2.0; 2.5)* | 1.0 (1.0; 2.0) | 2.0 (1.3; 2.0) |
| Total score | 4.5 (4.0; 5.0) | 6.0 (5.8; 7.0) | 4.5 (4.5; 6.5) | 5.8 (5.1; 6.8) |
For detailed description of the score for histological tissue analysis see Methods section.
*
P <0.05 vs. GR+/+ vehicle. PBS = phosphate buffered saline (vehicle), LPS = Lipopolysaccharide from Escherichia coli (055:B5), 10 mg·kg−1. Data is shown as median (interquartile range).