Figure 1.

Chemical reactions for the preparation of antibiotic drug nanocarriers (AgMUNH–Oflx NPs): attaching monolayer of 11-amino-1-undecanethiol onto the surface of (A) 2.4 ± 0.7, (B) 13.0 ± 3.1, and (C) 92.6 ± 4.4 nm NPs to prepare AgMUNH₂ NPs and then linking the amine group of 11-amino-1-undecanethiol with the carboxyl group of the Oflx via peptide bonds using 1-ethyl-3-[3-dimethylaminopropyl]-carbodiimide hydrochloride (EDC) and sulfo-N-hydroxysulfosuccinimide (NHS) as mediators to generate AgMUNH–Oflx NPs (antibiotic drug nanocarriers).³⁰