Table 2. TAND Checklist Severity Scores From All 3 Cohortsa.
| TAND Checklist Categories and Sections | Severity Score From the TAND Checklist, No. Endorsing/Total No. (%) | ||
|---|---|---|---|
| TSC | FTD | HC | |
| Behavioral total severity score, mean (SD) | 4.6 (3.04) | 5.07 (4.05) | 0.63 (1.2) |
| Outbursts | 5/16 (31) | 7/14 (50) | 0/16 |
| Tantrum | 3/16 (19) | 6/14 (43) | 0/16 |
| Repeating | 5/16 (32) | 4/15 (36) | 0/16 |
| Eye contact | 2/16 (12.5) | 5/14 (36) | 0/16 |
| Difficulty getting along | 3/16 (19) | 1/15 (7) | 0/16 |
| Repetitive behaviors | 5/16 (31) | 6/15 (40) | 0/16 |
| Rigid | 5/16 (31) | 6/15 (40) | 1/16 (6) |
| Overactivity | 6/16 (38) | 5/15 (33) | 1/16 (6) |
| Restlessness | 8/15 (53) | 6/15 (40) | 2/16 (13) |
| Impulsivity | 9/16 (56) | 9/15 (60) | 1/16 (6) |
| Difficulty eating | 6/16 (38) | 8/15 (53) | 0/16 (0) |
| Sleep difficulty | 12/16 (75) | 7/15 (47) | 4/16 (25) |
| Autism spectrum disorder | 0/16 | 0/15 (0) | 0/16 |
| ADHD | 3/16 (19) | 1/14 (7) | 1/16 (6) |
| Cognitive total severity score, mean (SD) | 4.62 (3.66) | 5.33 (3.26) | .5 (.73) |
| Delayed language | 3/15 (20) | 6/15 (40) | 0/16 |
| Difficulty with attention | 10/15 (67) | 9/15 (60) | 1/16 (6) |
| Reading | 4/15 (27) | 3/12 (25) | 2/16 (13) |
| Writing | 3/14 (21) | 1/12 (8) | 0/16 |
| Spelling | 2/14 (14) | 4/12 (33) | 0/16 |
| Mathematic | 10/15 (67) | 3/12 (25) | 2/16 (13) |
| Memory | 10/16 (63) | 9/15 (60) | 3/16 (19) |
| Attention | 10/16 (63) | 12/15 (80) | 0/16 |
| Multitasking | 7/16 (44) | 10/15 (67) | 0/16 |
| Visuospatial | 4/16 (25) | 7/15 (47) | 0/16 |
| Executive | 8/16 (50) | 10/15 (67) | 0/16 |
| Disorientation | 2/15 (13) | 7/15 (47) | 0/16 |
| Psychiatric total severity score, mean (SD) | 2.31 (1.85) | 2.5 (1.22) | .94 (1.06) |
| Anxiety | 13/16 (81) | 12/14 (86) | 4/16 (25) |
| Depressed | 10/16 (63) | 9/14 (64) | 6/16 (38) |
| Shyness | 4/16 (25) | 1/14 (7) | 2/16 (12.5) |
| Mood swing | 7/15 (47) | 10/15 (67) | 3/16 (19) |
| Self-injury | 2/15 (13) | 1/15 (7) | 0/16 |
| Obsessive | 3/16 (19) | 1/15 (7) | 0/16 |
| Psychotic | 0/15 | 1/15 (7) | 0/16 |
Abbreviations: ADHD, attention-deficit/hyperactivity disorder; FTD, frontotemporal dementia; HC, healthy control; TAND, tuberous sclerosis–associated neuropsychiatric disorders; TSC, tuberous sclerosis complex.
a
The TSC and FTD cohorts endorsed several behavioral and cognitive difficulties along with anxiety and depression. Because not all participants filled out every question, the denominators differ slightly between questions. To retain as much data as possible, we presented the data as percentages to account for differing sample sizes among items.