Table. Demographics and Baseline Clinical Characteristics.
| Characteristic | No. (%) | P Value | |||||||
|---|---|---|---|---|---|---|---|---|---|
| All | Western Europe | Eastern Europe | Western Pacific | South East Asia | North America | Central/South America | Eastern Mediterranean and Africa | ||
| No. of patients (in-hospital population) | 18 553 | 3594 (19.4) | 2802 (15.1) | 3354 (18.1) | 2329 (12.6) | 1592 (8.6) | 2641 (14.2) | 2241 (12.1) | NA |
| Patients who died during index stay, No. (%) | 451 (2.4) | 105 (2.9) | 41 (1.5) | 56 (1.7) | 37 (1.6) | 27 (1.7) | 116 (4.4) | 69 (3.1) | NA |
| Patients discharged alive, No. (%) | 18 102 (97.6) | 3489 (97.1) | 2761 (98.5) | 3298 (98.3) | 2292 (98.4) | 1565 (98.3) | 2525 (95.6) | 2172 (96.9) | NA |
| Countries, No. | 44 | 9 | 5 | 8 | 3 | 2 | 8 | 9 | NA |
| Sites, No. | 358 | 69 | 48 | 73 | 41 | 20 | 62 | 45 | NA |
| Demographic | |||||||||
| Age, mean (SD), y | 66.1 (13.92) | 72.3 (12.47) | 67.7 (11.56) | 65.4 (14.59) | 60.9 (13.02) | 63.2 (14.45) | 66.0 (14.46) | 63.0 (13.81) | <.001 |
| Median (IQR) | 67.0 (57-77) | 75.0 (65-81) | 68.0 (60-77) | 67.0 (56-77) | 61.0 (53-70) | 63.0 (54-74) | 67.0 (57-77) | 64.0 (55-73) | |
| ≥65 | 10 651 (57.4) | 2732 (76.0) | 1764 (63.0) | 1890 (56.4) | 955 (41.0) | 747 (46.9) | 1502 (56.9) | 1061(47.3) | |
| ≥75 | 5817 (31.4) | 1822 (50.7) | 910 (32.5) | 1072 (32.0) | 349 (15.0) | 365 (22.9) | 815 (30.9) | 484 (21.6) | |
| BMI | |||||||||
| No. | 8900 | 1849 | 1247 | 1717 | 959 | 1455 | 894 | 779 | <.001 |
| Mean (SD) | 28.7 (15.78) | 29.6 (7.23) | 29.9 (6.72) | 25.9 (31.63) | 24.6 (4.94) | 32.8 (11.44) | 28.0 (6.20) | 29.3 (7.10) | |
| Median (IQR) | 27.1 (24-32) | 28.1 (25-33) | 28.7 (25-33) | 24.4 (22-28) | 24.1 (21-27) | 30.7 (26-38) | 27.1 (24-31) | 27.7 (25-32) | |
| Male | 11 372 (61.3) | 2317 (64.5) | 1636 (58.4) | 2031 (60.6) | 1483 (63.7) | 937 (58.9) | 1576 (59.7) | 1392 (62.1) | |
| Race | |||||||||
| White | 9656 (52.0) | 3504 (97.5) | 2777 (99.1) | 95 (2.8) | 0 | 795 (49.9) | 1059 (40.1) | 1426 (63.6) | <.001 |
| Black | 867 (4.7) | 14 (0.4) | 0 | 2 (0.1) | 1 (0.0) | 705 (44.3) | 95 (3.6) | 50 (2.2) | |
| Asian | 5738 (30.9) | 24 (0.7) | 9 (0.3) | 3246 (96.8) | 2326 (99.9) | 27 (1.7) | 2 (0.1) | 104 (4.6) | |
| Native American | 375 (2.0) | 2 (0.1) | 0 | 0 | 0 | 8 (0.5) | 365 (13.8) | 0 | |
| Pacific Islander | 7 (0) | 2 (0.1) | 0 | 0 | 0 | 2 (0.1) | 3 (0.1) | 0 | |
| Other | 1910 (10.3) | 48 (1.3) | 16 (0.6) | 11 (0.3) | 2 (0.1) | 55 (3.5) | 1117 (42.3) | 661 (29.5) | |
| Medical history | |||||||||
| Hypertension | 11 807 (63.6) | 2260 (62.9) | 2241 (80.0) | 1846 (55.0) | 1109 (47.6) | 1226 (77.0) | 1785 (67.6) | 1340 (59.8) | <.001 |
| Prior MI/ACS | 3504 (18.9) | 745 (20.7) | 869 (31.0) | 555 (16.5) | 283 (12.2) | 324 (20.4) | 395 (15.0) | 333 (14.9) | |
| Prior CAD | 6381 (34.4) | 1090 (30.3) | 1481 (52.9) | 1180 (35.2) | 601 (25.8) | 628 (39.4) | 495 (18.7) | 906 (404) | |
| Atrial fibrillation/flutter | 5766 (31.1) | 1644 (45.7) | 1318 (47.0) | 824 (24.6) | 190 (8.2) | 608 (38.2) | 703 (26.6) | 479 (21.4) | |
| Valvular surgery or percutaneous valvular procedures | 771 (4.2) | 284 (7.9) | 110 (3.9) | 55 (1.6) | 27 (1.2) | 86 (5.4) | 108 (4.1) | 101 (4.5) | |
| COPD/asthma | 2655 (14.3) | 631 (17.6) | 524 (18.7) | 340 (10.1) | 143 (6.1) | 432 (27.1) | 358 (13.6) | 227 (10.1) | |
| Type 2 diabetes | 6808 (36.7) | 1317 (36.6) | 920 (32.8) | 1076 (32.1) | 972 (41.7) | 661 (41.5) | 815 (30.9) | 1047 (46.7) | |
| CKD | 3766 (20.3) | 965 (26.9) | 642 (22.9) | 519 (15.5) | 243 (10.4) | 539 (33.9) | 466 (17.6) | 392 (17.5) | |
| Anemia | 1614 (8.7) | 430 (12.0) | 380 (13.6) | 158 (4.7) | 61 (2.6) | 266 (16.7) | 149 (5.6) | 170 (7.6) | |
| Smoking status | |||||||||
| Current | 2532 (13.6) | 468 (13.0) | 405 (14.5) | 541 (16.1) | 242 (10.4) | 291 (18.3) | 202 (7.6) | 383 (17.1) | |
| Systolic BP, mm Hg | |||||||||
| No. | 16 995 | 3168 | 2479 | 3110 | 2162 | 1578 | 2363 | 2135 | <.001 |
| Mean (SD) | 133.3 (29.2) | 135.1 (28.1) | 137.3 (28.7) | 132.6 (28.3) | 132.0 (28.7) | 138.1 (31.9) | 128.2 (28.7) | 130.6 (30.4) | |
| Median (IQR) | 130 (110-150) | 131 (115-150) | 133 (120-155) | 130 (110-149) | 130 (110-150) | 134 (115-156) | 125 (109-143) | 126 (110-148) | |
| Heart rate, bpm | |||||||||
| No. | 16 932 | 3135 | 2477 | 3096 | 2159 | 1578 | 2362 | 2125 | <.001 |
| Mean (SD) | 89.4 (22.9) | 87.4 (23.4) | 88.5 (24.0) | 89.0 (22.4) | 94.0 (21.9) | 89.6 (21.2) | 87.3 (23.2) | 91.7 (22.3) | |
| Median (IQR) | 86 (73-102) | 84 (70-100) | 82 (70-100) | 86 (73-101) | 92 (80-107) | 87 (74-103) | 84 (71-100) | 90 (76-104) | |
| eGFR (MDRD), mL/min/1.73 m2 | |||||||||
| No. (%) | 11 282 (60.8) | 2055 (57.2) | 820 (29.3) | 1150 (34.3) | 2129 (91.4) | 1441 (90.5) | 2280 (86.3) | 1407 (62.8) | <.001 |
| Median (IQR) | 64.4 (44.7-87.1) | 63.8 (45.0-85.5) | 71.5 (50.4-96.3) | 63.8 (41.7-87.5) | 64.4 (45.3-87.2) | 56.8 (37.9-78.3) | 65.7 (46.2-86.6) | 67.1 (46.6-91.5) | |
Abbreviations: ACS, acute coronary syndrome; BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); BP, blood pressure; CAD, coronary artery disease; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate; IQR, interquartile range; MDRD, Modification of Diet in Renal Disease; MI, myocardial infarction; NA, not applicable.