Figure 3. Association Between Medial Temporal Tau Positron Emission Tomography (PET) and Apolipoprotein E ε4 (APOEε4) Stratified by Cognitive Status.

A, In cognitively unimpaired participants (n = 124), APOEε4 carriership was associated with fluorine 18–labeled [¹⁸F] MK6240 standardized uptake value ratio (SUVR) in the bilateral entorhinal cortex and hippocampus. In cognitively impaired participants (n = 100), APOEε4 carriership was associated with increased [¹⁸F]MK6240 in the bilateral hippocampus. B, In cognitively unimpaired patients (n = 157), APOEε4 carriership was associated with [¹⁸F]flortaucipir SUVR in the left entorhinal cortex. In cognitively impaired patients (n = 109), APOEε4 carriership was associated with increased [¹⁸F]flortaucipir in the bilateral entorhinal cortices and hippocampus. Age, sex, and amyloid-β SUVR were used as covariates in each model. Results remained similar when using partial volume–corrected PET data. CU indicates cognitively unimpaired; CI, cognitively impaired.