Table 2. Adjusted Direct and Indirect Associations of Depression With Arterial Stiffness Mediated via Metabolic Syndrome (MetS)a.
| Measure | Overall (N = 124 445) | Women (n = 71 799) | Men (n = 52 646) | |||
|---|---|---|---|---|---|---|
| β (95% CI) | P Value | β (95% CI) | P Value | β (95% CI) | P Value | |
| MetS | ||||||
| Total association | 0.35 (0.28-0.43) | <.001 | 0.38 (0.30-0.47) | <.001 | 0.27 (0.11-0.46) | <.001 |
| Direct association | 0.25 (0.17-0.32) | <.001 | 0.27 (0.19-0.34) | <.001 | 0.20 (0.03-0.42) | <.001 |
| Indirect association via MetS | 0.10 (0.07-0.13) | .001 | 0.11 (0.08-0.15) | .001 | 0.07 (0.01-0.14) | .004 |
| Proportion mediated, % | 29 | NA | 29 | NA | 26 | NA |
| MetS and high-sensitivity CRP | ||||||
| Total association | 0.35 (0.28-0.43) | <.001 | 0.38 (0.30-0.47) | <.001 | 0.27 (0.11-0.45) | <.001 |
| Direct association | 0.21 (0.15-0.28) | <.001 | 0.25 (0.18-0.33) | .002 | 0.13 (−0.03 to 0.26) | .070 |
| Indirect association | 0.13 (0.10-0.17) | <.001 | 0.13 (0.10-0.16) | .051 | 0.14 (0.09-0.22) | <.001 |
| Proportion mediated, % | 37 | NA | 34 | NA | 52 | NA |
Abbreviations: CRP, C-reactive protein, NA, not applicable.
a
Adjusted for age, sex, living in the most socioeconomically deprived areas by quintile, race/ethnicity, parental depression, hypertension, dyslipidemia, smoking, cancer, kidney disease, liver disease, chronic obstructive pulmonary disorders, and autoimmune disorders.