Table 3. Replication and Analysis of Association Results at Lead SNPs.

Locusa	Chr	Lead SNPb	Base Pairc	Allele 1/2	Discovery Cohort		Replication Cohorts						Discovery and Replication Analysis
							United States		Australia and Northern Ireland		Victoria, Australia
					Odds Ratio (95% CI)	P Value	Odds Ratio (95% CI)	P Value	Odds Ratio (95% CI)	P Value	Odds Ratio (95% CI)	P Value	P Value	Direction
PNPLA2	11	rs61876744	820754	T/C	0.59 (0.49-0.71)	7.46 × 10−9	0.77 (0.63-0.95)	8.88 × 10−4	0.84 (0.65-1.08)	.18	0.97 (0.79-1.19)	.76	2.45 × 10−8	−, −, −, −
MAML2	11	rs10831500	95982642	G/T	1.59 (1.33-1.91)	3.91 × 10−7	1.35 (1.11-1.65)	5.69 × 10−3	1.09 (0.85-1.40)	.52	1.03 (0.84-1.26)	.79	3.83 × 10−6	+, +, +, +
CSNK1E	22	rs138378	38796159	A/G	0.50 (0.41-0.61)	1.77 × 10−11	0.95 (0.78-1.16)	.79	0.97 (0.76-1.24)	.82	0.93 (0.76-1.13)	.45	3.18 × 10−4	−, −, −, −

Abbreviations: Chr, chromosome; CSNK1E, casein kinase I isoform epsilon; MAML2, mastermind-like transcriptional coactivator 2; PNPLA2, patatin-like phospholipase domain containing 2; SNP, single-nucleotide polymorphism.

^aLocus assigned to the RefSeq protein-coding gene within or near the association signal interval.

^bThe lead SNP at CSNK1E (rs138380) was not successfully genotyped in the Australia and Northern Ireland and Victoria, Australia, cohorts, and a proxy (rs138378, R² = 0.938) was used for replication instead.

^cGenomic positions are based on hg19.