Figure 3. Flow Diagram Showing Suggested Algorithm for Maintenance Strategies in Metastatic Colorectal Cancer.

FPIRI indicates fluoropyrimidine with irinotecan; FPOX, fluoropyrimidine with oxaliplatin.

^aThe same recommendations could be considered for FOLFOXIRI (fluorouracil, leucovorin, oxaliplatin, and irinotecan) with less supporting evidence.

^bMost of the maintenance trials used oxalipatin-based regimens. The fluoropyrimidine used can be either capecitabine or fluorouracil.

^cCan consider adding bevacizumab to the maintenance treatment with fluoropyrimidine if bevacizumab was added to the induction period.