Table 1. Demographics and Comorbidities of Necrobiotic Xanthogranuloma.
| Patient Characteristic | Patients, No./Total No. (%) | ||
|---|---|---|---|
| Multicenter Cohort (n = 34) | Systematic Review (n = 201) | Overall (n = 235) | |
| Age, mean (SD), y | 61.6 (14.1) | 61.9 (14.2) | 61.8 (14.2)a |
| Sex | |||
| Female | 23/34 (68) | 124/201 (61.7) | 147/235 (62.6) |
| Male | 11/34 (32) | 77/201 (38.3) | 88/235 (37.4) |
| Race | |||
| White | 32/33 (97) | 46/57 (81)a | 78/90 (87) |
| Asian | 0 | 11/57 (19) | 11/90 (12) |
| Black or African American | 1/33 (3) | 0 | 1/90 (1) |
| Paraproteinemia | 26/34 (76)b | 167/201 (83.1) | 193/235 (82.1) |
| IgG-κ | 15/34 (44) | 102/201 (50.7) | 117/235 (50.0) |
| IgG-λ | 8/34 (24) | 41/201 (20.4) | 49/235 (20.8) |
| IgM | 1/34 (3) | 4/201 (2.0) | 5/235 (2.1) |
| IgA | 2/201 (1.0) | 2/235 (0.8) | |
| Polyclonal | 2/34 (6) | 6/201 (3.0) | 8/235 (3.4) |
| Unspecified type | 12/201 (6.0) | 12/235 (5.1) | |
| Malignant condition | 8/34 (24)c | 51/201 (25.4) | 59/235 (25.1) |
| Multiple myeloma | 5/34 (15) | 28/201 (13.9) | 33/235 (14.0) |
| Lymphoma | 2/34 (6) | 13/201 (6.5) | 15/235 (6.4) |
| Leukemia | 1/34 (3) | 7/201 (3.5) | 8/235 (3.4) |
| Breast cancer | 0 | 1/201 (0.5) | 1/235 (0.4) |
| Rectal cancer | 0 | 1/201 (0.5) | 1/235 (0.4) |
| Waldenstrom macroglobulinemia | 0 | 1/201 (0.5) | 1/235 (0.4) |
a
One patient was identified as being of Hispanic or Latino ethnicity.
b
The timing of paraproteinemia relative to necrobiotic xanthogranuloma was antecedent in 13 of 24 patients (54%), concurrent in 6 of 24 individuals (25%), and subsequent in 4 of 24 patients (17%).
c
The timing of multiple myeloma relative to necrobiotic xanthogranuloma was subsequent in 5 of 5 patients (100%) at a time interval of up to 5.7 years (median [range], 2.4 [0.1-5.7] years). The timing of lymphoma and leukemia relative to necrobiotic xanthogranuloma was antecedent in 3 of 3 patients (100%).