Table. Number of Children, Length of Follow-up, and Type 1 Diabetes (T1D) Rates by Rotavirus Vaccination Statusa.
| Group | Children, No. (%) | Follow-up, y | No. Who Developed T1D | Rate/100 000 Person-Years | Crude Rate Ratio | Adjusted Hazard Ratio (95% CI)c | Sensitivity Analysis, Adjusted Hazard Ratio (95% CI) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SD)b | Median (Interquartile Range)b | Sum | 1d | 2e | ||||||
| Completed vaccination series | 1 035 198 (66) | 2.2 (2.2) | 1.5 (0.6-3.2) | 2 297 088 | 492 | 21.4 | 1.01 | 1.09 (0.87-1.36) | 1.14 (0.95-1.38) | 1.22 (0.96-1.55) |
| Partially vaccinated | 210 057 (13) | 2.4 (2.3) | 1.5 (0.6-3.5) | 497 374 | 100 | 20.1 | 0.95 | 1.03 (0.78-1.36) | 1.05 (0.82-1.35) | 1.18 (0.88-1.58) |
| Not vaccinated | 318 285 (20) | 2.9 (2.8) | 1.8 (0.7-4.3) | 909 692 | 192 | 21.1 | 1.00 | 1 [Reference] | 1 [Reference] | 1 [Reference] |
Including only children surviving to at least 12 months with continuous enrollment and without any T1D claims before that time, excluding 22 patients with T1D diagnosed before 2 months of age, 59 patients diagnosed between 2 and 12 months of age, and 283 children with only a single claim for T1D. Also excludes 1 290 972 children whose continuous enrollment lapsed before 12 months of age.
Numbers after the 1 year of compulsory follow-up (ie, total follow-up is this number plus 1 year).
Adjusted for year of birth and excluding 138 751 children who had never received any doses of tetanus-diphtheria-pertussis–containing vaccines; 95% CIs generated using robust standard errors.
Adjusted for year of birth and including all children followed up until at least 12 months of age with continuous enrollment and without any T1D claims before that time, without restrictions based on receipt of tetanus-diphtheria-pertussis–containing vaccines.
Adjusted for year of birth and excluding 138 751 children who had never received any doses of tetanus-diphtheria-pertussis–containing vaccines as well as an additional 92 616 children born into states with universal vaccine purchase programs (2006-2012: Alaska, Idaho, Maine, Massachusetts, New Hampshire, New Mexico, North Dakota, Oregon, Rhode Island, Vermont, Washington, Wisconsin, and Wyoming; 2013-2014: Connecticut, Idaho, Maine, Massachusetts, New Hampshire, New Mexico, Rhode Island, South Dakota, Vermont, Washington, and Wyoming; and 2015-2017: Alaska, Connecticut, Idaho, Maine, Massachusetts, New Hampshire, New Mexico, Rhode Island, Vermont, Washington, and Wyoming).