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. 2019 Dec 26;77(4):378–386. doi: 10.1001/jamapsychiatry.2019.4208

Figure 2. Longitudinal Prediction of Change in Internalization Problems From Ages 7 to 11 Years.

Figure 2.

A, Left dorsolateral prefrontal cortex (DLPFC) and subgenual anterior cingulate cortex (sgACC) predicted change in internalization (and anxiety/depression and withdrawn subscales) such that a greater anticorrelation at time 1 (age 7 years) predicted a worsening of internalization 4 years later (age 11 years). B, Scatterplot of longitudinal prediction. Negative change scores indicate improvement and positive change scores indicate decline over 4 years. C, Logistic regression using sgACC-DLPFC to predict internalization problems at time 4 (≥55), controlling for internalization scores at time 1 (t 1). The histograms represent the distribution of the risk of internalization problems at time 4 (t 4) (as predicted by sgACC-DLPFC connectivity at time 1) displayed separately for those participants with low (left) vs high (right) internalization problem scores at time 4.