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. 2019 Dec 26;77(4):378–386. doi: 10.1001/jamapsychiatry.2019.4208

Figure 3. Conceptual Replication/Clinical Extension.

Figure 3.

A, Longitudinal prediction of change in Child Behavior Checklist (CBCL) anxiety/depression symptoms over 3 years in children with (blue) or without (red) familial risk for depression. Baseline resting-state subgenual anterior cingulate cortex–dorsolateral prefrontal cortex (sgACC-DLPFC) connectivity predicted a change of anxiety/depression, such that less positive correlations at time 1 predicted a worsening of anxiety/depression scores 3 years later. B, Scatterplot of longitudinal prediction. Negative change scores indicate improvement, and positive change scores indicate decline over 3 years.