Table 2. Cognitive, Fluid Biomarker, and Imaging AUC Values From ROC Curve Analyses.

Variablea	AUC by Group Comparison
	Controls vs PSP-All	Controls vs CBS-All	PSP-All vs CBS-All	PSP-RS vs PSP-Cortical	PSP-RS vs PSP-Subcortical	PSP-Cortical vs PSP-Subcortical	CBS-AD vs CBS-4RT
MoCA	0.84	0.79	0.66	0.75	0.83	0.80	0.87
ECAS	0.91	0.83	0.61	0.73	0.82	0.80	0.80
ACE-III	0.94	0.88	0.64	0.76	0.81	0.81	0.80
Serum NF-L	0.88	0.91	0.72	0.74	0.83	0.75	0.76
Pons-midbrain ratio	0.69	0.73	0.84	0.71	0.58	0.60	0.66
Imaging region
Pons	0.76	0.92	0.78	0.59	0.58	0.70	0.57
Midbrain	0.89	0.91	0.56	0.63	0.65	0.60	0.60
Medulla	0.78	0.82	0.51	0.54	0.59	0.52	0.69
Cerebellum	0.59	0.79	0.55	0.73	0.54	0.80	0.63
Frontal lobe	0.80	0.71	0.75	0.76	0.70	0.89	0.57
Parietal lobe	0.69	0.60	0.73	0.73	0.60	0.84	0.69
Temporal lobe	0.79	0.67	0.77	0.65	0.60	0.75	0.51
Occipital lobe	0.59	0.63	0.61	0.72	0.52	0.78	0.54
Central structures	0.88	0.81	0.74	0.62	0.50	0.64	0.57
Ventricles	0.71	0.51	0.81	0.60	0.68	0.79	0.66

Abbreviations: ACE-III, Addenbrooke’s Cognitive Examination 3; AD, Alzheimer disease; AUC, area under the ROC curve; CBS, corticobasal syndrome; ECAS, Edinburgh Cognitive and Behavioural ALS (Amytrophic Lateral Sclerosis) Screen; 4RT, 4-repeat tau; MoCA, Montreal Cognitive Assessment; NF-L, neurofilament light chain; PSP, progressive supranuclear palsy; ROC, receiver operating characteristic; RS, Richardson syndrome.

^aCognitive scale and serum NF-L AUC values are based on logistic regression analyses that used sex, age at symptom onset, and disease duration at testing as covariates. Imaging group comparisons were adjusted for sex, age at scan, and total intracranial volume. An AUC of 0.80 or greater indicated high diagnostic accuracy.