Table 1. Patient Characteristics.
| Characteristics Measured at Study Enrollment | No. (%) | P Value | ||
|---|---|---|---|---|
| Overall (N = 832) | In-Hospital Followed by S/V | |||
| S/V (n = 417) | Enalapril (n = 415) | |||
| Age, mean (SD), y | 61 (14) | 61 (14) | 62 (14) | .23 |
| Women | 226 (27.2) | 104 (24.9) | 122 (29.4) | .15 |
| Race | ||||
| White | 487 (58.5) | 247 (59.2) | 240 (57.8) | .82 |
| Black | 297 (35.7) | 149 (35.7) | 148 (35.7) | |
| Asian | 15 (1.8) | 7 (1.7) | 8 (1.9) | |
| Other | 33 (4.0) | 14 (3.4) | 19 (4.6) | |
| Hispanic ethnicity | 73 (8.8) | 33 (7.9) | 40 (9.7) | .38 |
| Medical history | ||||
| Prior HF | 539 (64.8) | 281 (67.4) | 258 (62.2) | .19 |
| Atrial fibrillation | 298 (35.8) | 139 (33.3) | 159 (38.3) | .13 |
| Coronary disease | 227 (27.3) | 111 (26.6) | 116 (28.0) | .67 |
| Hypertension | 709 (85.2) | 364 (87.3) | 345 (83.1) | .09 |
| Diabetes | 157 (18.9) | 75 (18.0) | 82 (19.8) | .51 |
| CKD | 232 (27.9) | 120 (28.8) | 112 (27.0) | .57 |
| LVEF %, mean (SD) | 24 (8.0) | 24 (8.0) | 24 (7.9) | .93 |
| Vital signs, mean (SD) | ||||
| BMI | 32.1 (8.9) | 32.2 (9.0) | 32.1 (8.8) | .95 |
| BP, mm Hg | ||||
| Systolic | 122 (15.5) | 122 (14.9) | 122 (16.2) | .81 |
| Diastolic | 75 (12.7) | 76 (12.4) | 75 (13.0) | .37 |
| Laboratory data, median (IQR) | ||||
| NT-proBNP, pg/mL | 2685 (1479-5102) | 2883 (1602-5395) | 2515 (1351-4898) | .04 |
| BUN, mg/dL | 21 (17.0-28.0) | 22 (17.0-28.0) | 21 (16.0-28.0) | .96 |
| Serum Cr, mg/dL | 1.3 (1.1-1.5) | 1.3 (1.1-1.5) | 1.3 (1.1-1.5) | .84 |
| eGFR, mL/min 1.73 m2 | 59 (47.7-71.7) | 59 (48.0-71.8) | 59 (47.5-71.5) | .60 |
| Characteristics measured at week 8 before open-label extension, median (IQR) | ||||
| BP, mm Hg | ||||
| Systolic | 118 (105-131) | 118 (104-129) | 120 (108-133) | .04 |
| Diastolic | 70 (62-81) | 71 (62-82) | 70 (64-80) | .86 |
| NT-proBNP, pg/mL | 1526 (655-3334) | 1218 (522-3125) | 1630 (866-3423) | .005 |
| BUN, mg/dL | 19 (14.0-26.0) | 19 (14.0-26.0) | 20 (15.0-25.0) | .53 |
| Serum Cr, mg/dL | 1.2 (1.0-1.5) | 1.2 (1.0-1.5) | 1.2 (1.0-1.5) | .67 |
| eGFR, mL/min 1.73 m2 | 61 (47.2-76.1) | 63 (47.2-78.1) | 61 (47.1-74.4) | .21 |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); BP, blood pressure; BUN, blood urea nitrogen; CKD, chronic kidney disease; Cr, creatinine; eGFR, estimated glomerular filtration rate; HF, heart failure; LVEF, left ventricular ejection fraction; NT-proBNP, amino-terminal pro–B-type natriuretic peptide; S/V, sacubitril/valsartan.
SI conversion factors: To convert Cr to μmol/L, multiply by 76.25; and urea nitrogen to mmol/L, multiply by 0.357.