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In human peripheral nerve (tibial nerve), 4 hours of ischemia is followed by complete recovery of microvascular flow (blue) and nerve conduction (orange). After 6 hours of ischemia, there is a complete recovery of microvascular flow and almost complete recovery of nerve conduction. However, after more than 6 hours of ischemia, nerve conduction is almost completely lost. Reprinted with permission from JAMA Surgery.35
