Table 2.
Slit1–3 and Robo1–2 expression changes 7 days after mouse sciatic nerve transection injury
| Intact (Carr et al., 2017) | Proximal | Bridge | Distal | |
|---|---|---|---|---|
| Slit1 | Motor and sensory axons | Regenerating axons | Not expressed | Not expressed |
| Slit2 | Motor and sensory axons Schwann cells | Regenerating axons Schwann cells | Not expressed | Down-regulated in Schwann cells |
| Slit3 | Motor and sensory axons Schwann cells | Regenerating axons Schwann cells | Highly expressed in outermost layer of macrophages | Down-regulated in Schwann cells |
| Robo1 | Motor and sensory axons Schwann cells endothelial cells | Regenerating axons Schwann cells Endothelial cells | Up-regulated in migrating Schwann cells and Vimentin positive cells | Up-regulated in Schwann cells |
| Robo2 | Motor and sensory axons | Regenerating axons | Not expressed | Not expressed |
Robo: Roundabout.