Table 2. Multivariable Logistic Regression Model of Variables Associated With Short-term Hypocalcemia and Multivariable Random Effect Logistic Regression Analysis of Variables Associated With Long-term Hypocalcemia.
| Characteristic | Odds Ratio (95% CI) | |
|---|---|---|
| Short-term Hypocalcemiaa | Long-term Hypocalcemiaa | |
| Pathologic finding | ||
| Nodule | 1.0 [Reference] | 1.0 [Reference] |
| Goiter | 1.13 (0.89-1.43) | 1.11 (0.80-1.55) |
| Thyroiditis | 1.48 (1.16-1.89) | 1.60 (1.13-2.26) |
| Cancer | 1.32 (1.05-1.67) | 1.17 (0.83-1.63) |
| Age, y | ||
| 18-39 | 1.0 [Reference] | 1.0 [Reference] |
| 40-64 | 0.83 (0.78-0.87) | 0.73 (0.67-0.79) |
| Sex | ||
| Male | 1.0 [Reference] | 1.0 [Reference] |
| Female | 1.39 (1.29-1.50) | 1.69 (1.52-1.89) |
| Comorbidity score | ||
| 0 | 1.0 [Reference] | 1.0 [Reference] |
| 1 | 1.18 (1.05-1.31) | 1.28 (1.09-1.50) |
| ≥2 | 1.42 (1.11-1.80) | 1.63 (1.14-2.34) |
| Region | ||
| Northeast | 1.0 [Reference] | 1.0 [Reference] |
| North central | 1.01 (0.92-1.11) | 0.99 (0.86-1.14) |
| South | 1.01 (0.93-1.10) | 0.99 (0.87-1.13) |
| West | 1.03 (0.94-1.14) | 1.08 (0.94-1.25) |
| Census median income quintile | ||
| Very low | 1.0 [Reference] | 1.0 [Reference] |
| Low | 1.17 (1.07-1.29) | 1.33 (1.16-1.53) |
| Medium | 1.18 (1.07-1.30) | 1.28 (1.10-1.48) |
| High | 1.08 (0.96-1.20) | 1.08 (0.92-1.27) |
| Very high | 0.94 (0.85-1.05) | 0.94 (0.80-1.11) |
| Payerb | ||
| Comprehensive | 1.0 [Reference] | 1.0 [Reference] |
| HMO | 0.80 (0.65-0.98) | 0.85 (0.63-1.16) |
| POS | 0.78 (0.63-0.97) | 0.79 (0.57-1.09) |
| PPO | 0.99 (0.82-1.19) | 1.09 (0.82-1.46) |
| Other | 1.11 (0.91-1.37) | 1.10 (0.80-1.52) |
| MSA volume | ||
| Low | 1.0 [Reference] | 1.0 [Reference] |
| Medium | 0.97 (0.90-1.05) | 0.94 (0.84-1.05) |
| High | 0.94 (0.86-1.02) | 0.90 (0.79-1.03) |
| Central neck dissection | ||
| No | 1.0 [Reference] | 1.0 [Reference] |
| Yes | 1.15 (1.07-1.24) | 1.25 (1.12-1.40) |
| Lateral neck dissection | ||
| No | 1.0 [Reference] | 1.0 [Reference] |
| Yes | 1.51 (1.37-1.66) | 1.95 (1.69-2.26) |
| Parathyroid reimplantation | ||
| No | 1.0 [Reference] | 1.0 [Reference] |
| Yes | 1.58 (1.46-1.71) | 2.05 (1.82-2.31) |
| RLN injury | ||
| No | 1.0 [Reference] | 1.0 [Reference] |
| Yes | 1.49 (1.27-1.74) | 2.04 (1.64-2.54) |
| Vitamin D deficiency | ||
| No | 1.0 [Reference] | 1.0 [Reference] |
| Yes | 1.96 (1.74-2.21) | 3.72 (3.30-4.18) |
| Menopause | ||
| No | 1.0 [Reference] | 1.0 [Reference] |
| Yes | 1.09 (0.83-1.42) | 1.66 (1.36-2.04) |
| Magnesium disorder | ||
| No | 1.0 [Reference] | 1.0 [Reference] |
| Yes | 8.40 (7.21-9.79) | 25.23 (19.80-32.17) |
| Postoperative radiotherapy | ||
| No | 1.0 | |
| Yes | 1.26 (1.08-1.47) | |
| Postoperative radioactive iodine | ||
| No | 1.0 | |
| Yes | 1.42 (1.27-1.58) | |
Abbreviations: HMO, health maintenance organization; MSA, metropolitan statistical area; POS, point-of-service; PPO, preferred provider organization; RLN, recurrent laryngeal nerve.
a
Short-term is the first 30 days after surgery; long-term is 1 year after surgery.
b
Not known for all patients.