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. 2020 Jan 29;156(3):296–302. doi: 10.1001/jamadermatol.2019.4668

Table. Severity Label Definitions and Corresponding Treatment Intensity Groups Obtained From Initial Clinical Assessmentsa.

Acne Severity Level Treatment Intensity Group Associated Severity Label by Clinicians Final Clinical Severity Label Used in the Proposed Scale
1 No treatment necessary Clear Clear
2 Benzoyl peroxide wash and/or a mild topical retinoid Almost clear Almost clear
3 Benzoyl peroxide wash and a topical retinoid Mild Mild
4 Benzoyl peroxide wash and a stronger topical retinoid or a topical retinoid and consideration of an oral antibiotic Mild to moderate Mild to moderate
5 Benzoyl peroxide wash, topical treatment, and an oral antibiotic Moderate Moderate
6 Same as 5, but start considering isotretinoin Moderate to severe Moderate to less severe
7 Same as 5, but recommend isotretinoin Severe Less severe
8-9 Should be on isotretinoin (more severe = 8) (case 1) or, in very severe cases, start with a lower dosage of isotretinoin (to avoid flaring) and add corticosteroids (case 2) More severe Severe (case 1) or very severe (case 2)
a

Acne images were grouped into sets of lowest to highest perceived severity along with corresponding treatment intensities; severity labels were assigned to each group by clinicians in the initial experiments, and the final severity labels were definitions used in the proposed scale.