Table. Differences in Baseline and Worst Postbaseline Symptom Rates Between Patient and Clinician Reports.
| Symptom | Baseline, % | Worst Postbaseline, % | ||||||
|---|---|---|---|---|---|---|---|---|
| PRO | CTCAE | % Difference | P Value | PRO | CTCAE | % Difference | P Value | |
| Agitation | 62.6 | 13.9 | 48.7 | <.001 | 61.0 | 29.3 | 31.7 | <.001 |
| Anorexia | 75.0 | 44.8 | 30.2 | <.001 | 83.6 | 100 | –16.4 | <.001 |
| Anxiety | 58.4 | 25.9 | 32.5 | <.001 | 73.6 | 28.2 | 45.4 | <.001 |
| Cognitive disturbance | 45.1 | 5.1 | 40.0 | <.001 | 70.7 | 26.0 | 44.7 | <.001 |
| Constipation | 36.6 | 12.0 | 24.6 | <.001 | 68.5 | 33.7 | 34.8 | <.001 |
| Cough | 92.9 | 38.1 | 54.8 | <.001 | 75.0 | 100 | –25.0 | <.001 |
| Dermatitis | 4.2 | 1.2 | 3.0 | .059 | 65.3 | 81.4 | –16.1 | <.001 |
| Diarrhea | 64.0 | 4.0 | 60.0 | <.001 | 77.8 | 100 | –22.2 | <.001 |
| Diplopia | 8.5 | 0.6 | 7.9 | <.001 | 39.8 | 3.3 | 36.5 | <.001 |
| Dizziness | 35.1 | 15.1 | 20.0 | <.001 | 59.9 | 31.2 | 28.7 | <.001 |
| Dyspnea | 26.2 | 23.4 | 2.8 | .45 | 46.9 | 60.8 | –13.9 | .002 |
| Edema | 19.6 | 7.9 | 11.7 | <.001 | 43.4 | 32.7 | 10.7 | <.001 |
| Fatigue | 93.3 | 43.1 | 50.2 | <.001 | 98.9 | 96.7 | 2.2 | .10 |
| Headache | 50.2 | 21.1 | 29.1 | <.001 | 64.9 | 42.8 | 22.1 | <.001 |
| Hypopigmentation | 3.6 | 1.2 | 2.4 | .157 | 69.5 | 9.0 | 60.5 | <.001 |
| Insomnia | 58.0 | 37.0 | 21.0 | <.001 | 78.5 | 68.4 | 10.1 | .02 |
| Nausea | 45.7 | 22.4 | 23.3 | <.001 | 69.1 | 49.9 | 19.2 | <.001 |
| Pain | ||||||||
| Abdominal | 31.1 | 15.0 | 16.1 | <.001 | 43.5 | 28.8 | 14.7 | <.001 |
| Bone | 61.5 | 7.7 | 53.8 | <.001 | 66.7 | 54.9 | 11.8 | .05 |
| Burning | 21.1 | 0.6 | 20.5 | <.001 | 86.2 | 46.1 | 40.1 | <.001 |
| Myalgia | 54.0 | 20.0 | 34.0 | <.001 | 66.0 | 54.7 | 11.3 | .18 |
| Pruritus | 42.8 | 3.0 | 39.8 | <.001 | 88.6 | 73.1 | 15.5 | <.001 |
| Vision (blurred) | 8.5 | 4.5 | 4.0 | .11 | 39.8 | 18.8 | 21.0 | <.001 |
| Vomiting | 29.5 | 13.6 | 15.9 | <.001 | 37.8 | 26.6 | 11.2 | <.001 |
Abbreviations: CTCAE, Common Terminology Criteria for Adverse Events; PRO, patient-reported outcome.