Table 2.
Function and clinical relevance of the protein-coding genes containing the most differentially methylated promoters in warts
| Gene symbol | Gene name | Main physiological function |
|---|---|---|
| CYSLTR1 | Cysteinyl leukotriene receptor 1 | Mediates bronchoconstriction |
| C10orf99 | Chromosome 10 Open Reading Frame 99 | Mediates recruitment of lymphocytes to epithelia |
| KRT6B | Keratin 6B | Epithelial wound repair and inflammation |
| KLK2 | Kallikrein Related Peptidase 2 | Sperm liquefication |
| LAMA4 | Laminin Subunit Alpha 4 | Cell adhesion, differentiation, and migration |
| ALPK2 | Alpha Kinase 2 | Unknown |
| METTL7A | Methyltransferase Like 7A | Unknown |
| HSD17B14 | 17β-Hydroxysteroid dehydrogenase type 14 | Steroid metabolism |
| H3F3B | H3 Histone Family Member 3B | Found at sites of nucleosomal displacement |
| MST1L | Macrophage Stimulating 1 Like | Unknown |
| LTC4S | Leukotriene C4 Synthase | Involved in cysteinyl leukotriene biosynthesis |
| IZUMO1 | Izumo sperm-egg fusion 1 | Essential for fusion and binding of sperm and egg |
| FOLR3 | Folate receptor 3 | Mediate delivery of 5-methyltetrahydrofolate to cell interior |
| FXYD1 | FXYD Domain Containing Ion Transport Regulator 1 | Regulates ion channel activity |
| KRTAP2-4 | Keratin Associated Protein 2-4 | Involved in hair formation |
| KRTAP4-8 | Keratin Associated Protein 4-8 | Involved in hair formation |
| ADH7 | Alcohol dehydrogenase 7 | Functions in retinoic acid synthesis |
| KRT75 | Keratin 75 | Involved in hair and nail formation |
| FAM25A | Family with sequence similarity 25 member A | Unknown |
| ADIPOR2 | Adiponectin receptor 2 | Regulates glucose and lipid metabolism |