Table 3.
GO enrichment analysis showing the significant biological processes (BP) of the top 500 hypermethylated promoters.
| GOMFID | P-value | Odds ratio | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|---|
| GO:0009913 | 0 | 11.3215 | 2.1081 | 19 | 328 | epidermal cell differentiation |
| GO:0043588 | 0 | 9.3276 | 2.6737 | 20 | 409 | skin development |
| GO:0070268 | 0 | 14.8063 | 0.7126 | 9 | 110 | cornification |
| GO:0031424 | 0 | 13.9409 | 0.664 | 8 | 111 | keratinization |
| GO:0060429 | 0 | 3.7163 | 8.1779 | 25 | 1251 | epithelium development |
| GO:0042742 | 0 | 8.0356 | 1.5624 | 11 | 239 | defense response to bacterium |
| GO:0030154 | 0 | 2.5597 | 26.423 | 49 | 4042 | cell differentiation |
| GO:0006959 | 0 | 6.7129 | 1.4905 | 9 | 228 | humoral immune response |
| GO:0051707 | 0 | 3.5529 | 5.4585 | 17 | 835 | response to other organism |
| GO:0070488 | 0 | Inf | 0.0131 | 2 | 2 | neutrophil aggregation |
| GO:0031581 | 0 | 58.5596 | 0.0719 | 3 | 11 | hemidesmosome assembly |
| GO:0009607 | 1e-04 | 3.3622 | 5.7461 | 17 | 879 | response to biotic stimulus |
| GO:0048731 | 1e-04 | 2.1729 | 30.6198 | 50 | 4684 | system development |
| GO:0050832 | 1e-04 | 17.986 | 0.2549 | 4 | 39 | defense response to fungus |
| GO:0032502 | 2e-04 | 2.0271 | 40.0921 | 59 | 6133 | developmental process |
| GO:0016477 | 2e-04 | 2.639 | 9.1062 | 21 | 1393 | cell migration |
| GO:0090630 | 3e-04 | 9.5433 | 0.5753 | 5 | 88 | activation of GTPase activity |
| GO:0061844 | 5e-04 | 11.8647 | 0.3726 | 4 | 57 | antimicrobial humoral immune response mediated by antimicrobial peptide |
| GO:0009605 | 8e-04 | 2.5057 | 8.646 | 19 | 1419 | response to external stimulus |
| GO:0051674 | 8e-04 | 2.378 | 10.0018 | 21 | 1530 | localization of cell |
| GO:0007155 | 9e-04 | 2.4699 | 8.6421 | 19 | 1322 | cell adhesion |
| GO:0031338 | 0.001 | 9.819 | 0.4445 | 4 | 68 | regulation of vesicle fusion |
| GO:0097530 | 0.001 | 7.0599 | 0.7648 | 5 | 117 | granulocyte migration |
| GO:0002376 | 0.0014 | 2.0026 | 18.1078 | 31 | 2770 | immune system process |
| GO:0002523 | 0.0018 | 38.6782 | 0.0654 | 2 | 10 | leukocyte migration involved in inflammatory response |
| GO:0030595 | 0.0019 | 4.9654 | 1.2943 | 6 | 198 | leukocyte chemotaxis |
| GO:0040011 | 0.002 | 2.1602 | 11.4792 | 22 | 1756 | locomotion |
| GO:1904995 | 0.0022 | 34.3786 | 0.0719 | 2 | 11 | negative regulation of leukocyte adhesion to vascular endothelial cell |
| GO:0045104 | 0.0023 | 12.6396 | 0.2615 | 3 | 40 | intermediate filament cytoskeleton organization |
| GO:0030593 | 0.0025 | 7.5626 | 0.5687 | 4 | 87 | neutrophil chemotaxis |
| GO:0003334 | 0.0027 | 30.9389 | 0.0784 | 2 | 12 | keratinocyte development |
| GO:0032119 | 0.0027 | 30.9389 | 0.0784 | 2 | 12 | sequestering of zinc ion |
| GO:0008219 | 0.0029 | 2.0056 | 14.1398 | 25 | 2163 | cell death |
| GO:0030856 | 0.003 | 5.4424 | 0.9806 | 5 | 150 | regulation of epithelial cell differentiation |
| GO:0018119 | 0.0032 | 28.1246 | 0.085 | 2 | 13 | peptidyl-cysteine S-nitrosylation |
| GO:0034497 | 0.0032 | 28.1246 | 0.085 | 2 | 13 | protein localization to phagophore assembly site |
| GO:0032101 | 0.0034 | 2.6778 | 4.8571 | 12 | 743 | regulation of response to external stimulus |
| GO:0022408 | 0.0036 | 5.2242 | 1.0198 | 5 | 156 | negative regulation of cell-cell adhesion |
| GO:0006928 | 0.0045 | 1.979 | 13.0285 | 23 | 1993 | movement of cell or subcellular component |
| GO:0006935 | 0.0049 | 2.8124 | 3.8177 | 10 | 584 | chemotaxis |
| GO:0045087 | 0.0051 | 2.4353 | 5.7853 | 13 | 885 | innate immune response |
| GO:0003336 | 0.0065 | Inf | 0.0065 | 1 | 1 | corneocyte desquamation |
| GO:0021593 | 0.0065 | Inf | 0.0065 | 1 | 1 | rhombomere morphogenesis |
| GO:0021660 | 0.0065 | Inf | 0.0065 | 1 | 1 | rhombomere 3 formation |
| GO:0021666 | 0.0065 | Inf | 0.0065 | 1 | 1 | rhombomere 5 formation |
| GO:0033037 | 0.0065 | Inf | 0.0065 | 1 | 1 | polysaccharide localization |
| GO:0034516 | 0.0065 | Inf | 0.0065 | 1 | 1 | response to vitamin B6 |
| GO:0035644 | 0.0065 | Inf | 0.0065 | 1 | 1 | phosphoanandamide dephosphorylation |
| GO:0043420 | 0.0065 | Inf | 0.0065 | 1 | 1 | anthranilate metabolic process |
| GO:0045660 | 0.0065 | Inf | 0.0065 | 1 | 1 | positive regulation of neutrophil differentiation |
| GO:0072046 | 0.0065 | Inf | 0.0065 | 1 | 1 | establishment of planar polarity involved in nephron morphogenesis |
| GO:0072740 | 0.0065 | Inf | 0.0065 | 1 | 1 | cellular response to anisomycin |
| GO:1905716 | 0.0065 | Inf | 0.0065 | 1 | 1 | negative regulation of cornification |
| GO:0006950 | 0.008 | 1.6938 | 24.6188 | 36 | 3766 | response to stress |
| GO:1903036 | 0.0081 | 7.7836 | 0.4118 | 3 | 63 | positive regulation of response to wounding |
| GO:0050729 | 0.0082 | 5.354 | 0.791 | 4 | 121 | positive regulation of inflammatory response |
| GO:0030539 | 0.0082 | 16.2749 | 0.1373 | 2 | 21 | male genitalia development |
| GO:1902807 | 0.0087 | 5.2634 | 0.8041 | 4 | 123 | negative regulation of cell cycle G1/S phase transition |
| GO:0045606 | 0.0098 | 14.7231 | 0.1504 | 2 | 23 | positive regulation of epidermal cell differentiation |
| GO:0001775 | 0.0099 | 2.0563 | 8.459 | 16 | 1294 | cell activation |