Table 4.

GO enrichment analysis showing the significant molecular functions (MF) of the top 500 hypermethylated promoters.

GOMFID	P-value	Odds ratio	ExpCount	Count	Size	Term
GO:0050786	0	99.375	0.0655	4	11	RAGE receptor binding
GO:0017137	1e-04	7.2337	1.0653	7	179	Rab GTPase binding
GO:0035662	1e-04	340.8367	0.0179	2	3	Toll-like receptor 4 binding
GO:0050544	3e-04	113.5986	0.0298	2	5	arachidonic acid binding
GO:0005200	4e-04	8.9173	0.613	5	103	structural constituent of cytoskeleton
GO:0045294	0.0019	37.8526	0.0655	2	11	alpha-catenin binding
GO:0036041	0.0022	34.0653	0.0714	2	12	long-chain fatty acid binding
GO:0008146	0.0035	10.7307	0.3035	3	51	sulfotransferase activity
GO:0001856	0.006	Inf	0.006	1	1	complement component C5a binding
GO:0005130	0.006	Inf	0.006	1	1	granulocyte colony-stimulating factor receptor binding
GO:0030429	0.006	Inf	0.006	1	1	kynureninase activity
GO:0036458	0.006	Inf	0.006	1	1	hepatocyte growth factor binding
GO:0047888	0.006	Inf	0.006	1	1	fatty acid peroxidase activity
GO:0061981	0.006	Inf	0.006	1	1	3-hydroxykynureninase activity
GO:1901567	0.0096	14.7995	0.1488	2	25	fatty acid derivative binding