Table 5.
GO enrichment analysis showing the significant biological processes (BP) of the top 500 hypomethylated promoters.
| GOMFID | P-value | Odds ratio | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|---|
| GO:1901750 | 0 | 102.821 | 0.0789 | 4 | 8 | leukotriene D4 biosynthetic process |
| GO:0006751 | 0 | 82.2519 | 0.0888 | 4 | 9 | glutathione catabolic process |
| GO:0006691 | 0 | 21.5282 | 0.2861 | 5 | 29 | leukotriene metabolic process |
| GO:0046456 | 1e-04 | 12.589 | 0.4538 | 5 | 46 | icosanoid biosynthetic process |
| GO:0051572 | 3e-04 | 203.1707 | 0.0296 | 2 | 3 | negative regulation of histone H3-K4 methylation |
| GO:0006575 | 4e-04 | 4.9708 | 1.7363 | 8 | 176 | cellular modified amino acid metabolic process |
| GO:0072268 | 6e-04 | 101.5793 | 0.0395 | 2 | 4 | pattern specification involved in metanephros development |
| GO:0048762 | 9e-04 | 4.3203 | 1.9829 | 8 | 201 | mesenchymal cell differentiation |
| GO:0072081 | 9e-04 | 67.7154 | 0.0493 | 2 | 5 | specification of nephron tubule identity |
| GO:0022612 | 0.0012 | 5.4916 | 1.1739 | 6 | 119 | gland morphogenesis |
| GO:0040012 | 0.0012 | 2.2988 | 9.4409 | 20 | 957 | regulation of locomotion |
| GO:0030155 | 0.0015 | 2.5831 | 6.2347 | 15 | 632 | regulation of cell adhesion |
| GO:0030334 | 0.0016 | 2.3435 | 8.2867 | 18 | 840 | regulation of cell migration |
| GO:0051893 | 0.0018 | 8.3709 | 0.5229 | 4 | 53 | regulation of focal adhesion assembly |
| GO:0017144 | 0.0018 | 2.3773 | 7.6948 | 17 | 780 | drug metabolic process |
| GO:0048293 | 0.002 | 40.6244 | 0.0691 | 2 | 7 | regulation of isotype switching to IgE isotypes |
| GO:0086036 | 0.002 | 40.6244 | 0.0691 | 2 | 7 | regulation of cardiac muscle cell membrane potential |
| GO:0032412 | 0.002 | 3.7493 | 2.269 | 8 | 230 | regulation of ion transmembrane transporter activity |
| GO:0033598 | 0.0023 | 12.7584 | 0.2664 | 3 | 27 | mammary gland epithelial cell proliferation |
| GO:0071493 | 0.0026 | 33.8516 | 0.0789 | 2 | 8 | cellular response to UV-B |
| GO:1902041 | 0.0027 | 7.455 | 0.582 | 4 | 59 | regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| GO:0035148 | 0.003 | 4.523 | 1.4107 | 6 | 143 | tube formation |
| GO:0016064 | 0.0031 | 5.4155 | 0.9865 | 5 | 100 | immunoglobulin mediated immune response |
| GO:0033689 | 0.0033 | 29.0139 | 0.0888 | 2 | 9 | negative regulation of osteoblast proliferation |
| GO:0045869 | 0.0033 | 29.0139 | 0.0888 | 2 | 9 | negative regulation of single stranded viral RNA replication via double stranded DNA intermediate |
| GO:0070383 | 0.0033 | 29.0139 | 0.0888 | 2 | 9 | DNA cytosine deamination |
| GO:0072048 | 0.0033 | 29.0139 | 0.0888 | 2 | 9 | renal system pattern specification |
| GO:0051270 | 0.0034 | 2.1328 | 9.579 | 19 | 971 | regulation of cellular component movement |
| GO:0043001 | 0.0035 | 10.9332 | 0.3058 | 3 | 31 | Golgi to plasma membrane protein transport |
| GO:0032409 | 0.0035 | 3.421 | 2.4761 | 8 | 251 | regulation of transporter activity |
| GO:0071526 | 0.0038 | 10.5555 | 0.3157 | 3 | 32 | semaphorin-plexin signaling pathway |
| GO:0043648 | 0.0038 | 5.1432 | 1.0358 | 5 | 105 | dicarboxylic acid metabolic process |
| GO:0001756 | 0.0041 | 6.6105 | 0.6511 | 4 | 66 | somitogenesis |
| GO:0009972 | 0.0041 | 25.3857 | 0.0987 | 2 | 10 | cytidine deamination |
| GO:0046087 | 0.0041 | 25.3857 | 0.0987 | 2 | 10 | cytidine metabolic process |
| GO:0035510 | 0.0041 | 10.2031 | 0.3255 | 3 | 33 | DNA dealkylation |
| GO:0048870 | 0.0043 | 1.8716 | 15.0936 | 26 | 1530 | cell motility |
| GO:0070988 | 0.0048 | 6.3043 | 0.6807 | 4 | 69 | demethylation |
| GO:0030307 | 0.0048 | 4.0729 | 1.5587 | 6 | 158 | positive regulation of cell growth |
| GO:0034754 | 0.0049 | 4.8503 | 1.095 | 5 | 111 | cellular hormone metabolic process |
| GO:0060766 | 0.005 | 22.5637 | 0.1085 | 2 | 11 | negative regulation of androgen receptor signaling pathway |
| GO:0007045 | 0.0056 | 6.0251 | 0.7103 | 4 | 72 | cell-substrate adherens junction assembly |
| GO:0060429 | 0.0058 | 1.9184 | 12.3412 | 22 | 1251 | epithelium development |
| GO:0001867 | 0.006 | 20.3061 | 0.1184 | 2 | 12 | complement activation, lectin pathway |
| GO:0016554 | 0.006 | 20.3061 | 0.1184 | 2 | 12 | cytidine to uridine editing |
| GO:0046133 | 0.006 | 20.3061 | 0.1184 | 2 | 12 | pyrimidine ribonucleoside catabolic process |
| GO:0072520 | 0.006 | 20.3061 | 0.1184 | 2 | 12 | seminiferous tubule development |
| GO:0048513 | 0.0067 | 1.5794 | 33.344 | 47 | 3380 | animal organ development |
| GO:0032101 | 0.0068 | 2.1741 | 7.3298 | 15 | 743 | regulation of response to external stimulus |
| GO:0001838 | 0.007 | 4.4295 | 1.1937 | 5 | 121 | embryonic epithelial tube formation |
| GO:0045995 | 0.007 | 4.4295 | 1.1937 | 5 | 121 | regulation of embryonic development |
| GO:0010566 | 0.007 | 18.459 | 0.1282 | 2 | 13 | regulation of ketone biosynthetic process |
| GO:0002699 | 0.007 | 3.7491 | 1.6869 | 6 | 171 | positive regulation of immune effector process |
| GO:0016053 | 0.0076 | 2.6059 | 4.0447 | 10 | 410 | organic acid biosynthetic process |
| GO:0045668 | 0.0076 | 8.0512 | 0.4045 | 3 | 41 | negative regulation of osteoblast differentiation |
| GO:0090382 | 0.0076 | 8.0512 | 0.4045 | 3 | 41 | phagosome maturation |
| GO:0050772 | 0.0077 | 5.4604 | 0.7793 | 4 | 79 | positive regulation of axonogenesis |
| GO:1901888 | 0.0081 | 5.3882 | 0.7892 | 4 | 80 | regulation of cell junction assembly |
| GO:0000722 | 0.0081 | 16.9197 | 0.1381 | 2 | 14 | telomere maintenance via recombination |
| GO:0042446 | 0.0084 | 5.3179 | 0.7991 | 4 | 81 | hormone biosynthetic process |
| GO:0001667 | 0.0085 | 2.56 | 4.1137 | 10 | 417 | ameboidal-type cell migration |
| GO:0030278 | 0.0092 | 3.5327 | 1.7856 | 6 | 181 | regulation of ossification |
| GO:0010959 | 0.0092 | 2.6793 | 3.5317 | 9 | 358 | regulation of metal ion transport |
| GO:1904062 | 0.0094 | 2.8684 | 2.9299 | 8 | 297 | regulation of cation transmembrane transport |
| GO:0000415 | 0.0099 | Inf | 0.0099 | 1 | 1 | negative regulation of histone H3-K36 methylation |
| GO:0003147 | 0.0099 | Inf | 0.0099 | 1 | 1 | neural crest cell migration involved in heart formation |
| GO:0030209 | 0.0099 | Inf | 0.0099 | 1 | 1 | dermatan sulfate catabolic process |
| GO:0035713 | 0.0099 | Inf | 0.0099 | 1 | 1 | response to nitrogen dioxide |
| GO:0044345 | 0.0099 | Inf | 0.0099 | 1 | 1 | stromal-epithelial cell signaling involved in prostate gland development |
| GO:0046901 | 0.0099 | Inf | 0.0099 | 1 | 1 | tetrahydrofolylpolyglutamate biosynthetic process |
| GO:0048694 | 0.0099 | Inf | 0.0099 | 1 | 1 | positive regulation of collateral sprouting of injured axon |
| GO:0050928 | 0.0099 | Inf | 0.0099 | 1 | 1 | negative regulation of positive chemotaxis |
| GO:0060598 | 0.0099 | Inf | 0.0099 | 1 | 1 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis |
| GO:0061713 | 0.0099 | Inf | 0.0099 | 1 | 1 | anterior neural tube closure |
| GO:0061767 | 0.0099 | Inf | 0.0099 | 1 | 1 | negative regulation of lung blood pressure |
| GO:0071250 | 0.0099 | Inf | 0.0099 | 1 | 1 | cellular response to nitrite |
| GO:0071954 | 0.0099 | Inf | 0.0099 | 1 | 1 | chemokine (C-C motif) ligand 11 production |
| GO:0072168 | 0.0099 | Inf | 0.0099 | 1 | 1 | specification of anterior mesonephric tubule identity |
| GO:0072169 | 0.0099 | Inf | 0.0099 | 1 | 1 | specification of posterior mesonephric tubule identity |
| GO:0072184 | 0.0099 | Inf | 0.0099 | 1 | 1 | renal vesicle progenitor cell differentiation |
| GO:0072259 | 0.0099 | Inf | 0.0099 | 1 | 1 | metanephric interstitial fibroblast development |
| GO:0090246 | 0.0099 | Inf | 0.0099 | 1 | 1 | convergent extension involved in somitogenesis |
| GO:0098749 | 0.0099 | Inf | 0.0099 | 1 | 1 | cerebellar neuron development |
| GO:1900281 | 0.0099 | Inf | 0.0099 | 1 | 1 | positive regulation of CD4-positive, alpha-beta T cell costimulation |
| GO:1904328 | 0.0099 | Inf | 0.0099 | 1 | 1 | regulation of myofibroblast contraction |
| GO:1904635 | 0.0099 | Inf | 0.0099 | 1 | 1 | positive regulation of glomerular visceral epithelial cell apoptotic process |
| GO:1904877 | 0.0099 | Inf | 0.0099 | 1 | 1 | positive regulation of DNA ligase activity |
| GO:1905580 | 0.0099 | Inf | 0.0099 | 1 | 1 | positive regulation of ERBB3 signaling pathway |
| GO:1905943 | 0.0099 | Inf | 0.0099 | 1 | 1 | negative regulation of formation of growth cone in injured axon |
| GO:2000080 | 0.0099 | Inf | 0.0099 | 1 | 1 | negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation |
| GO:2000184 | 0.0099 | Inf | 0.0099 | 1 | 1 | positive regulation of progesterone biosynthetic process |
| GO:2000572 | 0.0099 | Inf | 0.0099 | 1 | 1 | positive regulation of interleukin-4-dependent isotype switching to IgE isotypes |