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. 2020 Jan 1;16(3):515–528. doi: 10.7150/ijbs.34517

Figure 4.

Figure 4

Blockade of NF-κB ammeliorates CNH-induced PAH and pulmonary vascular remodeling. PDTC treatment suppressed CNH-induced increase in RVSP (A) and RV/(LV+S) (B). CNH exposure significantly increased RVSP (C) and RV/(LV+S) ratio (D) in WT but not in KO mice. (E) Representative images of the pulmonary vascular remodeling in lung sections subjected to Masson trichrome staining in WT and KO mice. (F) Quantitative analysis of pulmonary arterial wall area/total cross area (WA/TA). Values shown are means±s.e.m. N=5-8 per group. *p<0.05, **p<0.01 vs. Normoxia. #p<0.05, ##p<0.01 vs. CNH. PA, pulmonary artery. BR, bronchiole.